西洛他唑与氯吡格雷治疗下肢动脉硬化闭塞症的成本-效果分析

Cost-Effectiveness Analysis of Cilostazol and Clopidogrel in the Treatment of Lower Extremity Arteriosclerosis Obliterans

目的探讨西洛他唑与硫酸氢氯吡格雷片治疗下肢动脉硬化闭塞症的成本-效果。方法选取2016年2月至2017年2月青岛大学附属医院收治的下肢动脉硬化闭塞症患者150例作为研究对象,按治疗方法不同分为西洛他唑组(n=75)和氯吡格雷组(n=75),比较两组患者的临床疗效、血小板聚集率、成本-效果,并进行敏感性分析。结果西洛他唑组患者静息痛、冷感、麻木、溃疡及间歇性跛行治疗有效率与氯吡格雷组比较,差异无统计学意义(P>0.05);以显效率作为评价治疗效果的重要指标,西洛他唑组患者治疗静息痛、冷感、麻木、溃疡及间歇性跛行的成本-效果比(C/E)均低于氯吡格雷组,差异有统计学意义(P<0.05);两组治疗后血小板聚集率比较,差异无统计学意义(P>0.05)。结论西洛他唑与氯吡格雷治疗下肢动脉硬化闭塞症的各种症状疗效相当,但西洛他唑成本相对更低。

Objective To explore the cost-effectiveness of Cilostazole and clopidogrel bisulfate tablets in the treatment of lower extremity arteriosclerosis obliterans. Methods A total of 150 patients with lower extremity arteriosclerosis obliterans admitted to the Affiliated Hospital of Qingdao University from February 2016 to February 2017 were selected as the study subjects. They were divided into cilostazol group(n=75) and clopidogrel group(n=75) according to different treatment methods. The clinical efficacy, platelet aggregation rate, cost-effectiveness and sensitivity of the 2 groups were compared. Results There was no significant difference in the efficacy of resting pain, cold feeling, numbness, ulcer and intermittent claudication between cilostazol group and clopidogrel group(P>0.05). The significant efficiency was taken as an important index to evaluate the therapeutic effect. The success of treatment of resting pain, cold feeling, numbness, ulcer and intermittent claudication in Cilostazole group was compared with clopidogrel group. The C/E ratio was lower than that of clopidogrel group(P<0.05), and there was no significant difference in platelet aggregation rate between the 2 groups after treatment(P>0.05). Conclusion The efficacy of Cilostazole and Clopidogrel in the treatment of lower extremity arteriosclerosis obliterans is comparable, but the cost of Cilostazole is relatively lower.