细胞缝隙连接通讯功能检测方法的研究进展

Research progress on determination methods of intercellular gap junction communication function

细胞缝隙连接通讯(GJIC)是细胞间重要的通讯方式之一,已在兽医学科的相关研究中得到广泛应用。目前对缝隙连接检测方法的应用和评议并不统一。本文从代谢偶联、电化学生理、染料偶联三个方面,介绍GJIC功能的检测方法和应用,并对各种检测方法在实际应用中所表现出优势和局限性进行了阐述和探讨,为缝隙连接通讯检测方法的选择和联合应用提供参考。

Gap junctional intercellular communication(GJIC)is one of the most important communication modes between cells.At present,the application and evaluation of gap junction detection methods is not uniform.This paper introduces the detection methods and applications of GJIC function from three aspects:metabolic coupling,electrochemical physiology and dye coupling,and further elaborates and discusses the advantages and limitations of various detection methods in practical application.This paper provides a reference for the selection and joint application of gap connection communication detection methods.