丹红注射液治疗冠心病的作用机制与临床疗效

Mechanism and Clinical Efficacy of Danhong Injection in Treatment of Coronary Heart Disease

冠心病是全球最主要的疾病死亡原因之一,已成为全球重大公共卫生问题。冠心病属于中医学"胸痹"范畴,以心血瘀阻证最为常见。丹红注射液是由活血化瘀药丹参、红花提取制备而成,具有活血化瘀、通脉舒络的功效,具有抗炎症损伤、抗细胞凋亡、保护血管内皮、抑制血小板聚集、降血脂,抗凝血及改善血液流变学等作用,能改善心肌缺血,缓解心绞痛症状。现临床将丹红注射液广泛应用于冠心病的各个阶段,包括稳定型心绞痛、不稳定型心绞痛、急性心肌梗死,经皮冠状动脉介入治疗(PCI)术后、缺血性心肌病,冠心病合并心律失常、高脂血症、心力衰竭及糖尿病等。

Coronary heart disease(CHD)is one of the leading causes of death in the world and has become a major public health problem worldwide.CHD belongs to the category of"chest stuffiness"in traditional Chinese medicine,and the blood stasis syndrome is the most common syndrome.Danhong injection is prepared from the extract of Salviae Miltiorrhizae Radix et Rhizoma and Carthami Flos.It has the functions of promoting blood circulation and removing blood stasis.It has anti-inflammatory damage,anti-apoptosis,protection of vascular endothelium,inhibition of platelet aggregation,anti-hyperlipidemia,anticoagulation,improvement of blood rheology and other effects.It also could improve myocardial ischemia and relieve angina symptoms.Danhong injection is widely used in various stages of CHD,including stable angina pectoris,unstable angina pectoris,acute myocardial infarction,postoperative percutaneous coronary intervention(PCI),ischemic cardiomyopathy,CHD with arrhythmia,CHD with hyperlipidemia,CHD with heart failure and CHD with diabetes.