苗族医气阻血瘀证现代科学内涵探索以及苗族药抗妇炎胶囊干预机制研究

Exploration of modern scientific connotation of Miao medicine Qizu Xueyu syndrome and intervention mechanism of Kangfuyan Capsules

为了探索苗族医气阻血瘀证的现代科学内涵以及苗族药抗妇炎胶囊对气阻血瘀证的干预机制,该研究在苗族医药理论指导下,构建能够表征苗族医气阻血瘀证的实验动物模型,从一般体征、血脂指标、血清生化指标及免疫指标等角度探索气阻血瘀证的现代科学内涵;进而,对相关实验动物给予抗妇炎胶囊进行干预,观察抗妇炎胶囊对所构建的实验动物模型异常生理生化指标的纠正情况。结果显示,模型动物表现出精神萎靡,被毛粗糙,黯淡无光泽等体征变化,扭体行为变化极为明显;低密度脂蛋白胆固醇、磷酸肌酸激酶、Ig G、尿素氮、肌酐、直接胆红素、尿素、尿胆、肝脏指数显著高于空白组(P<0.01);血糖、胸腺指数显著低于空白组(P<0.01)。抗妇炎胶囊给药干预后,实验动物的生理及精神状态转好,体质量增加,扭体行为改善;磷酸肌酸激酶显著高于气阻血瘀组(P<0.01)、直接胆红素显著低于气阻血瘀组(P<0.01);免疫指标无显著性差异;尿胆原恢复正常;潜血、酮体有明显改善。由此可见,苗族医气阻血瘀证的现代科学内涵特征可表现为平滑肌痉挛造成局部缺血和组织细胞损伤、感染、肝肾功能异常;抗妇炎胶囊通过缓解子宫平滑肌痉挛、改善局部血液循环、修复肌肉细胞损伤、保肝、改善肾功能等途径发挥相关功效。

The aim of this paper was to explore the modern scientific connotation of Qizu Xueyu syndrome in Miao medicine and the intervention mechanism of Kangfuyan Capsules on Qizu Xueyu syndrome.Under the guidance of the theory of Miao medicine,an experimental animal model was constructed to characterize Qizu Xueyu syndrome in Miao medicine,and its modern scientific connotation was explored from the perspectives of general signs,blood lipid index,serum biochemical index and immune index.Furthermore,the relevant experimental animals were given Kangfuyan Capsules for intervention,then observed the corrective effect of Kangfuyan Capsules on abnormal physiological and biochemical indexes of the experimental animal model.The model animals showed signs such as mental depression,rough coat,dull and glossy,and the writhing behavior changed significantly.Low density lipoprotein cholesterol,creatine phosphate kinase,Ig G,urea nitrogen,creatinine,direct bilirubin,urea,urinary biliary and liver index were significantly higher than those in the blank group(P<0.01).The blood sugar and thymus index were significantly lower than those in the blank group(P<0.01).After the intervention of Kangfuyan Capsules,the physiological and mental state of the experimental animals improved,their weight increased and their writhing behavior improved.Creatine phosphate kinase(CK)was significantly higher than that of Qizu Xueyu group(P<0.01),direct bilirubin was significantly lower than that of Qizu Xueyu group(P<0.01),immune indexes had no significant difference,urinary bilirubin returned to normal.The modern scientific connotation of Qizu Xueyu syndrome in Miao medicine can be characterized by ischemia,tissue and cell damage,infection and abnormal liver and kidney function caused by smooth muscle spasm.Kangfuyan Capsules can relieve uterine smooth muscle spasm,improve local blood circulation,repair muscle cell injury,protect liver and improve renal function.