针刺“太冲”对自发性高血压大鼠血压影响的时效性

Effects of Acupuncture at “Taichong”(LR3) on Time-Effect of Lowering Blood Pressure in Spontaneously Hypertensive Rats

目的观察针刺"太冲"对自发性高血压大鼠(SHR)血压影响的时效性。方法将32只SHR随机分为太冲组、非穴组、莫索尼定组、模型组,另8只WKY大鼠为正常组。先监测各组大鼠干预前血压值,然后太冲组针刺"太冲",非穴组针刺大鼠后肢足背第三、四跖骨之间凹陷处,莫索尼定组予莫索尼定溶液0.04 mg/(kg·d)灌胃,模型组与正常组只作抓取等处理,各组均干预7天。第1次干预后30、60、90 min分别监测各组大鼠的血压值。第7天24、48、72 h后分别监测各组大鼠疗程后的血压值。结果与正常组同时间比较,模型组大鼠不同时间收缩压与舒张压均显著升高(P<0.05)。与模型组、非穴组比较,太冲组首次干预后30、60 min及疗程后24、48、72 h收缩压与舒张压均显著下降(P<0.05),莫索尼定组首次干预后30、60、90 min及疗程后24、48、72 h收缩压与舒张压均显著下降(P<0.05)。与太冲组比较,莫索尼定组首次干预后60、90 min及疗程后48、72 h收缩压与舒张压均显著下降(P<0.05)。与本组前一时间点比较,太冲组首次干预后30 min较干预前、疗程后24 h较首次干预后90 min收缩压与舒张压均显著下降(P<0.05);莫索尼定组首次干预后30 min较干预前、干预后60 min较30 min、疗程后24 h较首次干预后90 min收缩压与舒张压均显著下降(P<0.05)。结论针刺"太冲"与灌胃莫索尼定均可有效降低SHR大鼠血压,且针刺"太冲"与莫索尼定口服在首次干预后30 min时降压效果基本相当。

Objective To observe the time-effect of acupuncture at"Taichong"(LR3)on the blood pressure of spontaneously hypertensive rats(SHR).Methods A total of 32 SHRs were randomly divided into a Taichong group,a non-acupoint group,a moxonidine group and a model group.Another 8 Wistarkyoto(WKY)rats were set as a normal group.The blood pressure values of the rats in each group were monitored first,then the Taichong group acupunctured Timeliness,the non-acupoint group had acupuncture at the hollow area between the third and fourth metatarsal bones,and the moxonidine group was intragastrically administered with moxonidine solution 0.04 mg/(kg·d),and the model group as well as the normal group were only treated by grasping.Each group was intervened for 7 days.After the first intervention,the blood pressure values at 30,60,and 90 min after intervention were monitored.After 7 days of intervention,the blood pressure values of each group were monitored at 24,48 and 72 hours after the treatment.Results Compared with the normal group at the same time,the systolic blood pressure and diastolic blood pressure of the model group were significantly increased(P<0.05).Compared with the model group and the non-acupoint group,the systolic and diastolic blood pressures decreased significantly at 30,60 min after the first intervention and 24,48,and 72 h after treatment cours in the Taichong group(P<0.05),and systolic blood pressure and diastolic blood pressure in the moxonidine group were significantly decreased at 30,60,90 mins after the first intervention,24,48,and 72 h after treatment(P<0.05).Compared with the Taichong group,systolic blood pressure and diastolic blood pressure at 60 and 90 min after the first intervention and 48 and 72 h after the treatment were significantly decreased(P<0.05)in the moxonidine group.For the previous time point within the group,the systolic blood pressure and diastolic blood pressure in the Taichong group were significantly decreased 30 min after the first intervention compared with the pre-intervention,and 24 h after the first intervention compared with 90 min after first intervention(P<0.05),and the systolic and diastolic blood pressures in the moxonidine group were lowered significantly at 30 min after the first intervention than those before intervention,60 min after intervention than 30 min,24 h after treatment than 90 min after the first intervention(P<0.05).Conclusion Acupuncture at"Taichong"(LR3)of SHR and oral moxonidine could effectively reduce the blood pressure of SHR rats,and acupuncture at"Tai Chong"and intragastrical administration of moxonidine have basically the same antihypertensive effect 30 minutes after the first intervention.