2种营养支持疗法对腹泻型肠易激综合征患者的营养状况及生活质量的影响

Effect of parenteral and enteral nutrition support therapy on the nutritional status and quality of life of patients with diarrhea predominant irritable bowel syndrome

目的对比分析2种营养支持疗法对腹泻型肠易激综合征患者的营养状况及生活质量的应用效果。方法选取2015年3月-2018年1月哈尔滨医科大学附属第四医院收治的腹泻型肠易激综合征患者160例,采用随机数字表法将患者分为对照组和观察组,每组80例,对照组患者实施常规的肠外营养支持,观察组采取肠内营养支持,观察并比较2组患者的临床疗效、治疗前后营养指标的变化以及生活质量的情况。结果观察组的总有效率为91.2%,对照组的总有效率为80.0%,观察组高于对照组,差异具有统计学意义(P<0.05);治疗前,2组患者的清蛋白、血清前蛋白以及血红蛋白差异无统计学意义(均P>0.05);治疗后,观察组患者的清蛋白、血清前蛋白以及血红蛋白指标均高于对照组,差异具有统计学意义(均P<0.05);治疗前,2组患者的精神状态、日常社交、情绪状况和精力改变比较差异无统计学意义(均P>0.05);治疗后,观察组患者的精神状态、日常社交、情绪状况和精力改变均高于对照组,差异具有统计学意义(均P<0.05);观察组并发症发生率低于对照组,差异具有统计学意义(P<0.05)。结论营养支持疗法对腹泻型肠易激综合征患者的营养状况及生活质量的应用效果显著,且肠内营养效果更明显,能提高患者营养各指标,提高患者的生活质量,降低并发症的发生率。

Objective To compare the effects of parenteral and enteral nutrition support therapy on the nutritional status and quality of life of the patients with diarrhea predominant irritable bowel syndrome.Methods A total of 160 cases of diarrhea predominant irritable bowel syndrome(IBS-D)in the Fourth Hospital Affiliated to Harbin Medical University from March 2015 to January 2018 were randomly divided into control group and observation group by random digital table,with 80 cases in each group.The control group received routine parenteral nutrition support,while the observation group took parenteral nutrition and enteral nutrition support.The clinical efficacy of the two groups,the changes of nutritional indexes before and after the treatment and the quality of life of the patients were observed and compared.Results The total effective rate in the observation group was 91.2%,which was higher than that in the control group(80.0%),the difference was statistically significant(P<0.05);Before the treatment,the levels of serum albumin,prealbumin and hemoglobin between the two groups were no statistical significance(all P>0.05);after the treatment,the levels of serum albumin,prealbumin and hemoglobin in the observation group were higher than those in the control group,the difference was statistically significant(all P<0.05).Before the treatment,there were no statistical significance between the two groups in the daily social,emotional and mental state,and the energy of patients(all P>0.05);however,after the treatment,the daily social,emotional and mental state,and the energy of patients were improved obviously as compared with the control group,the difference was statistical significance(all P<0.05).The incidence of complications in the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Nutritional support therapy has significant effect on nutritional status and quality of life in patients with diarrhea predominant irritable bowel syndrome,and enteral nutrition is more effective as compared with the parenteral nutrition support.It can improve nutritional indicators and quality of life of patients,reduce the incidence of complications,and is worthy of clinical promotion.