血清睾酮水平与前列腺癌发生和进展的相关性探讨

The Relevance of Serum Testosterone Level to the Occurrence and Progression of Prostate Cancer

前列腺癌(prostate cancer,PCa)是一种世界范围内发病率极高的恶性肿瘤,Huggins最初认为血清睾酮(testosterone,T)的升高会增加患前列腺癌的风险,但现在越来越多的研究表明与血清睾酮水平与前列腺癌的发病风险、病理分期、术后评估有着相当复杂的相关性。近年来,我国前列腺癌的发病率一直呈上升的趋势,虽然血清睾酮水平与前列腺癌之间的联系已建立,但血清睾酮水平与前列腺癌的关系的病理机制尚没有统一的说法,其确切的病理生理机制仍不清楚。本文主要从发病风险,病理分期和术后评估等方面对血清睾酮水平与前列腺癌发生和进展的相关性进行综述。

Prostate cancer is a malignant tumor with a very high incidence worldwide. Huggins initially believed that increased serum testosterone level would increase the risk of prostate cancer, but now more and more studies have shown a rather complicated correlation between serum testosterone level and the risk of prostate cancer,pathological staging, and postoperative evaluation. In recent years, the incidence of prostate cancer in China has been on the rise. Although the relationship between serum testosterone level and prostate cancer has been established,there is still no unified statement on the pathological mechanism of the relationship between serum testosterone level and prostate cancer, and the exact pathophysiological mechanism remains unclear. In this article, the role of serum testosterone levels in the diagnosis and treatment of prostate cancer was reviewed from the perspectives of risk,pathological staging and postoperative evaluation.