康复新液联合泮托拉唑和凝血酶治疗消化性溃疡并出血的临床效果评价

Convalescent fluid with pantoprazole and thrombin in treatment of peptic ulcer with hemorrhage: clinical evaluation

目的探究康复新液联合泮托拉唑和凝血酶治疗消化性溃疡并出血的临床效果。方法选取山东省胶州市人民医院消化内科2014年9月至2016年2月收治的114例消化性溃疡并出血患者进行回顾性研究。参照组患者(57例)常规临床治疗,研究组患者(57例)常规治疗基础上采取康复新液联合泮托拉唑和凝血酶方案治疗,对比两组溃疡治疗效果、止血效果、腹痛消失时间、药物副作用。结果研究组患者治疗后溃疡愈合总有效率为98.25%,低于参照组,P<0.05;观察组患者止血总有效率为98.25%低于参照组85.96%,P<0.05;观察组患者腹痛消失时间短于参照组,P<0.05;观察组总不良反应率(3.51%)与参照组相当(1.75%),P>0.05。结论康复新液联合泮托拉唑和凝血酶治疗消化性溃疡并出血的临床效果显著,患者溃疡愈合好,止血效果好,复发率低,患者症状改善,药物毒副作用低,安全性高,可临床推广。

Objective To explore the clinical effect of kangfuxin fluid combined with pantoprazole and thrombin in the treatment of peptic ulcer complicated with bleeding. Methods A retrospective study was conducted on 114 patients with peptic ulcer complicated with bleeding admitted to the Department of Gastroenterology, People’s Hospital of Jiaozhou City, Shandong Province from September 2014 to February 2016. Patients in control group(57 cases) received conventional clinical treatment, and patients in the study group(57 cases) received conventional treatment on the basis of convalescent fluid combined with pantoprazole and thrombin, and the ulcer treatment effect, hemostatic effect, abdominal pain disappearance time and drug side effects were compared between the two groups. Results The total effective rate of ulcer healing in the study group was 98.25%, lower than that in the control group(P<0.05). The total effective rate of hemostasis in the study group was 98.25% lower than that in the control group(85.96%)(P< 0.05). The disappearance time of abdominal pain in the study group was shorter than that in the control group(P<0.05). The total adverse reaction rate(3.51%) in the study group was the same as that in the control group(1.75%)(P>0.05). Conclusion The clinical effect of kangfuxin liquid combined with pantoprazole and thrombin in the treatment of peptic ulcer complicated with bleeding is remarkable. The ulcer healing of patients is favorable, with good hemostatic effect and low recurrence rate and the symptoms of patients are improved;the toxic and side effects of the therapy are lower, and the safety is higher, and therefore it can be promoted clinically.