锌在生物磷灰石中的晶体化学研究进展

The progress in the researches on the crystal chemistry of zinc in bioapatite

Zn在生物磷灰石中的晶体化学行为不同于在地质体中,传统的磷灰石类质同像替代理论对生物磷灰石中的Ca位替换并不完全适用。为了解释生物磷灰石中Zn的出现,本文对已知的生物磷灰石中Zn的存在情况、Zn对Ca的替代机制以及Zn替代对生物磷灰石的影响等内容进行了综述,并就Zn在生物磷灰石中的晶体化学研究对人体肿瘤诊疗的启示作用进行了简单的讨论。理论和实验均表明Zn可以进入生物磷灰石晶格,占据有Ca缺陷的磷灰石晶格中的Ca2位空缺,使局部结构整体收缩。Zn的掺入对生物磷灰石的晶粒尺寸、结晶度、晶胞参数等均会产生较大的影响。当Zn被固定在人体肿瘤伴有的病理性钙化晶格中时,其可能对周围组织及体液中的Zn含量产生影响,进而影响人体内Zn的新陈代谢。

The crystal chemical behavior of zinc in bioapatite is different from that in geological body,thus the traditional theory of apatite isomorphism substitution is not completely applicable to the Ca site substitution in bioapatite.In order to explain the appearance of zinc in bioapatite,the authors made a review on the existence of zinc and the mechanism of zinc substitution for Ca site and the influence of zinc substitution in this paper.The implications of crystal chemistry of zinc in bioapatite on the diagnosis and treatment of human tumors were also discussed.Both theoretical and experimental results show that zinc incorporation into bioapatite can take place by occupying the Ca2 vacancy of the defect complex and the local structure would shrink as a whole.The substitution of zinc would have a great impact on crystallite dimension,crystallinity,cell parameters and so on.When zinc is fixed in the lattice of pathological calcification associated with human tumors,it might affect the zinc content in surrounding tissues and body fluids,thus affecting the metabolism of zinc in human body.