青石止痒软膏治疗进行期寻常型银屑病血热内蕴证观察

Clinical Observation of Qingshi Zhiyang Ointmentin in Treating Blood Heat Type Progressive Psoriasis Vulgaris

目的:观察青石止痒软膏(曾用名:甘石青黛膏)治疗进行期寻常型银屑病(血热内蕴证)的临床疗效和安全性。方法:采用阳性药物随机平行对照研究方法,将符合标准的120例进行期寻常型银屑病(血热内蕴证)随机分为观察组和对照组各60例,观察组青石止痒软膏外涂联合复方青黛胶囊口服,对照组卡泊三醇软膏外涂联合复方青黛胶囊口服,疗程4周。评估治疗0、4周患者银屑病皮损面积与严重程度指数(PASI)、瘙痒指数(VAS)、屏障功能、皮肤病生活质量评分(DLQI),评价临床疗效。结果:①完成观察组51人,总有效率82.35%;对照组57人,总有效率87.71%,2组总有效率相比差异无统计学意义(P>0.05);②治疗4周后,2组PASI评分、DLQI评分与治疗前差异均具有统计学意义(P<0.05)。治疗4周后,观察组皮损处水分值与治疗前差异具有统计学意义(P<0.05),对照组皮损处水分、油分值与治疗前差异均无统计学意义(P>0.05)。治疗4周后,观察组VAS评分与治疗前差异具有统计学意义(P<0.05),对照组VAS评分与治疗前差异无统计学意义(P>0.05);③治疗前及治疗后,2组间PASI评分、皮损处水分及油分值、DLQI评分、VAS评分差异均无统计学意义(P>0.05)。结论:青石止痒软膏治疗进行期寻常型银屑病(血热内蕴证)使用安全,疗效确切,其止痒、修复皮肤屏障效果优于达力士软膏。

Objective:To observe the effects and safety of Qingshi Zhiyang Ointmentin(used name:Ganshi Qingdai Ointmentin)in treating progressive psoriasis vulgaris(blood-heat type)patients.Methods:The 120 cases of progressive psoriasis vulgaris(blood-heat type)were randomly divided into the observation group and the control group,60 cases in each group.The observation group was treated with Qingshi Zhiyang Ointmentin combined Compound Qingdai Capsules,while the control group was treated Capptriol Ointment combined with compound Qingdai capsules for 4 weeks as a course.The psoriasis lesion area and severity index(PASI),the VAS pain scores(VAS),the barrier function and the dermatology life quality index(DLQI)were evaluated and recorded to evaluate the clinical efficacy comprehensively.Results:(1)There were 51 patients in the observation group,with a total effective rate of 82.35%.There were 57 patients in the control group,with the total effective rate of 87.71%.There was no statistically significant difference in the total effective rate between the two groups(P>0.05).(2)After 4 weeks of treatment,the PASI scores and DLQI scores were significantly lower than those before the treatment in both two group(P<0.05);There were statistically significant differences in moisture scores in the observation group(P<0.05)but no differences in neither moisture or oil scores in the control group(P>0.05);After 4 weeks of treatment,the VAS scores in the observation group got statistically significant lower than before(P<0.05),while the same indicators in the control group had no statistically significant changed(P>0.05).(3)There were no statistically significant differences in PASI scores,skin moisture and oil scores,DLQI scores and VAS scores between the two groups before and after the treatment(P>0.05).Conclusion:Qingshi Zhiyang Ointmentin is safe and effective in the treatment of progressive psoriasis vulgaris(blood-heat type),and it received a better effect on relieving itching and repairing skin barrier than Capptriol Ointment.