阿托伐他汀联合法舒地尔治疗老年不稳定性心绞痛的有效性及机制

Effectiveness and Mechanism of Atorvastatin Combined with Fasudil in the Treatment of Older Patients with Unstable Angina Pectoris

目的探讨阿托伐他汀联合法舒地尔治疗老年不稳定性心绞痛(UAP)的效果及机制.方法选取102例老年UAP患者随机分成常规治疗组60例和联合治疗组42例,两组除扩冠、抗凝等治疗外,前者给予口服10 mg阿托伐他汀,每日1次,后者在阿托伐他汀治疗基础上给予2 ml法舒地尔注射液加生理盐水50 ml静脉滴注,每日2次,疗程14 d.选取20例健康人为正常对照组.所有病例入选前及治疗后取静脉血,酶联免疫法(ELISA)测定血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和五聚素3(PTX-3)水平.结果老年UAP患者血清TNF-α、IL-6和PTX-3水平均明显高于正常对照组(P<0.01);治疗后联合治疗组总有效率明显高于常规治疗组(P<0.05);联合治疗组治疗后血清TNF-α、IL-6和PTX-3水平均明显低于常规治疗组(P<0.01).结论阿托伐他汀联合法舒地尔能更好地抑制老年UAP患者的炎症反应,对老年UAP患者有较好的治疗效果.

Objective To investigate the effectiveness and mechanism of atorvastatin combined with fasudil in older patients with unstable angina pectoris (UAP). Methods 102 older patients with UAP were randomly divided into the conventional treatment group (60 cases) and the combined treatment group (42 cases). The conventional treatment group was given oral 10 mg atorvastatin once a day. The combined treatment group was given oral 10 mg atorvastatin once a day and intravenous drip of 2 ml fasudil twice a day for 14 days. 20 healthy persons were assigned to the control group. The levels of tumor necrosis factor-α (TNF-α), interleu-kin-6 (IL-6) and pentraxin 3 (PTX-3) in serum were measured by ELISA. Results The levels of serum TNF-α, IL-6 and PTX-3 in older patients with UAP were significantly higher than those in the control group (P<0. 01). After treatment, the overall response rate in the combined treatment group was significantly higher than that in the conventional treatment group (P<0. 05). The levels of serum TNF-α, IL-6 and PTX-3 in the combined treatment group were significantly lower than those in the conventional treatment group (P<0. 01). Conclusion Atorvastatin combined with fasudil inhibits effectively the inflammatory reaction and ex-hibits good therapeutic effect in older patients with UAP.