内质网应激在阿霉素引起的心肌损伤中作用的研究进展

Progress in the Study of Endoplasmic Reticulum Stress in Myocardial Injury Induced by Doxorubicin

阿霉素是一种广谱抗肿瘤抗生素,但是由于剂量依赖性心脏毒性作用而引起阿霉素心肌病,致其使用受到限制.阿霉素心肌病的发病机制目前了解的仍不透彻,从近几年的研究来看,普遍认为其与心肌细胞凋亡机制相关.在众多凋亡发生机制中,作为一条新的细胞凋亡信号转导通路——内质网应激反应参与并介导凋亡的发生,为阿霉素心肌病的发生发展提供了新思路.本文通过对内质网应激在阿霉素心肌病中的作用机制和最新进展进行综述,为临床的研究提供理论依据.

Doxorubicin is a broad-spectrum anti-tumor antibiotic.The use of doxorubicin was limited due to dose-de-pendent cardiotoxicity,which leads to cardiomyopathy.The pathogenesis of doxorubicin cardiomyopathy is still poorly understood.Some evidences suggest that it is related to apoptosis of cardiomyocytes.The endoplasmic reticulum stress signal pathway mediates ap-optosis,which provides a new idea for the pathogenesis of doxorubicin cardiomyopathy.This paper summarizes the recent progress of endoplasmic reticulum stress in doxorubicin-induced cardiomyopathy.