糖尿病器官缺血再灌注损伤的研究进展

Research progress on ischemia-reperfusion injury of diabetic organs

糖尿病是一种发病率极高的代谢紊乱性疾病,患者的血糖长期处于较高水平,通过炎性反应、氧化应激等机制介导细胞损伤。缺血-再灌注损伤(IRI)是缺血器官在恢复血流灌注后其损伤进一步加重的现象,它在脑梗死、心肌梗死、肾IRI、肠IRI和肝IRI的病理生理机制中有重要影响,这些都是导致器官损伤(包括移植失败)甚至死亡的主要原因。近年来的研究显示,糖尿病会加重器官的IRI。本文就主要糖尿病脏器IRI的研究进展进行综述。

Diabetes is a high incidence of metabolic disorders,the patient′s blood sugar stayed high for a long time,cell damage is mediated by inflammatory response and oxidative stress.Ischemia-reperfusion injury(IRI)is a phenomenon that the injury of ischemic organs is further aggravated after the restoration of blood perfusion.It plays an important role in the pathophysiological mechanism of cerebral infarction,myocardial infarction,renal IRI,intestinal IRI and liver IRI.These are the leading causes of organ damage,including transplant failure,and even death.Recent studies have shown that diabetes can worsen IRI in organs.This paper reviews the research progress of IRI in major diabetic organs.