妊娠期高血压疾病患者血清LRRFIP1水平与血小板功能的关系

Relationship between serum LRRFIP1 level and platelet function in patients with hypertensive disorder complicating pregnancy

目的探讨妊娠期高血压疾病患者血清富亮氨酸重复序列相互作用蛋白1(LRRFIP1)水平与患者血小板功能的相关性。方法将2016年1月~2018年12月山东省枣庄市妇幼保健院(以下简称“我院”)收治的150例妊娠期高血压疾病患者纳入观察组,根据病情严重程度将观察组分为妊娠高血压组(n=59)、轻度子痫前期组(n=48)、重度子痫前期组(n=43)。另选同期在我院进行产前检查的健康妊娠期妇女50名为对照组。检测对比两组血清LRRFIP1水平、血小板功能指标血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW),并采用Pearson检验分析LRRFIP1水平与血小板功能指标PLT、MPV、PDW间的相关性。结果观察组患者的LRRFIP1、MPV、PDW高于对照组,而PLT则低于对照组,差异有统计学意义(P<0.05)。随着患者妊娠高血压病变程度加重,患者的LRRFIP1、MPV、PDW水平逐渐升高,而PLT水平则逐渐降低,组间比较差异有统计学意义(P<0.05)。Pearson相关性分析示,LRRFIP1与PLT呈负相关(r=-0.471,P=0.009),与MPV、PDW呈正相关(r=0.396、0.364,P=0.012、0.016)。结论LRRFIP1随着妊娠期高血压疾病患者病情的发生、发展的变化而改变,提示LRRFIP1可能参与妊娠期高血压疾病的发病过程,并可能影响患者血小板功能。

Objective To investigate the correlation between serum leucine repeat sequence interacting protein 1(LRRFIP1)and platelet function in patients with hypertensive disorder complicating pregnancy.Methods From January 2016 to December 2018,150 patients with hypertensive disorder complicating pregnancy in Zaozhuang Maternal and Child Health Hospital of Shandong Province(hereinafter referred to as“our hospital”)were selected as the observation group,and patients in the observation group were divided into pregnancy hypertension group(n=59),mild preeclampsia group(n=48)and severe preeclampsia group(n=43)according to the severity of patients′condition.Another 50 healthy pregnant women who underwent prenatal examination in our hospital during the same period were selected as the control group.Serum levels of LRRFIP1,platelet count(PLT),mean platelet volume(MPV)and platelet distribution width(PDW)were measured and compared between the two groups.The correlation between LRRFIP1 level and PLT,MPV and PDW was analyzed by Pearson test.Results The levels of LRRFIP1,MPV and PDW of the observation group were higher than those of the control group,while the PLT was lower than that of the control group,and the differences between the two groups were statistically significant(P<0.05).In the observation group,the levels of LRRFIP1,MPV and PDW gradually increased,while the levels of PLT gradually decreased with the aggravation of pregnancy induced hypertension,and the differences among the three groups were statistically significant(P<0.05).Pearson correlation test showed that LRRFIP1 was negatively correlated with PLT(r=-0.471,P=0.009)and positively correlated with MPV and PDW(r=0.396,0.364;P=0.012,0.016).Conclusion LRRFIP1 changes with the changes in the occurrence and development of the patients with hypertensive disorder complicating pregnancy,indicating that LRRFIP1 may be involved in the pathogenesis of hypertensive disorder complicating pregnancy and may affect the function of platelet.