自噬在结核分枝杆菌感染中作用的研究进展

The Research Progress of Autophagy in Mycobacterium tuberculosis Infection

结核病是一种由结核分枝杆菌感染引发的全球致死性传染病。结核分枝杆菌感染巨噬细胞后其在胞内的命运与细胞自噬的发生息息相关。但是,由于结核分枝杆菌与细胞自噬之间的博弈过程十分复杂且机制尚未完全阐明。因此,该文以结核分枝杆菌感染巨噬细胞后经典自噬和LAP对结核病发生发展的作用为切入点,从自噬抗结核分枝杆菌感染与结核分枝杆菌破坏自噬发生两个方面阐述了自噬与结核分枝杆菌之间的相互作用,从而为结核病发病机制的研究提供新的思路和视角。

The infection of Mycobacterium tuberculosis(Mtb)is the cause of tuberculosis(TB),which remains a fatal rate in most parts of the world.The mechanism of the interaction between Mtb and host cell is complicated and unclear.Moreover,the fate of Mtb and macrophage are related with autophagy.In this context,we summarize current knowledge about the role of autophagy in Mtb infection.By mostly morphological and mechanically studies,it showed that autophagy can effectively suppress Mtb infection to macrophage.Oppositely,Mtb break the autophagic process by self-protection.In light of the interaction between autophagy and Mycobacterium tuberculosis,it provides novel insights for studying pathogensis and physiological control of tuberculosis.