高迁移率族蛋白1与类风湿性关节炎的相关性研究进展

Research progress on the correlation between high mobility group box chromosomal protein l and rheumatoid arthritis

类风湿性关节炎是一种以关节病变为主要表现,以关节滑膜为主的慢性非特异性炎症性疾病,病程呈进行性发展。高迁移率族蛋白1作为一种潜在的炎症诱导因素参与了多种自身免疫性疾病的病程演变及发展。并且高迁移率族蛋白1的异常表达与类风湿性关节炎的发生发展密切相关。本文进一步阐述论证类风湿性关节炎患者血清中高迁移率族蛋白1的表达促进其炎性因素相关受体表达上调,但其与临床指标的相关性尚不明确;类风湿性关节炎患者滑膜中高迁移率族蛋白1的表达促进滑膜炎性表达;高迁移率族蛋白l在类风湿性关节炎滑膜成纤维细胞合成并释放炎性细胞因子、病理性增殖凋亡及自噬以及表型转变的不可逆性进展中起到的促进作用。理论上,其为类风湿性关节炎的临床诊断及病情干预提供新的作用靶点。

Rheumatoid arthritis is a chronic non-specific inflammatory disease of the joint synovium with joint lesions as the main manifestation, and the course of disease is progressive. High mobility group box chromosomal protein 1 is involved in the evolution and progression of various autoimmune diseases as a potential inflammation-inducing factor.And the abnormal expression of high mobility group box chromosomal protein 1 is closely related to the occurrence and development of rheumatoid arthritis. This article further elaborates and demonstrates that the expression of high mobility group box chromosomal protein 1 in serum of patients with rheumatoid arthritis promotes the up-regulation of inflammatory factor-related receptors, but its correlation with clinical indicators is still unclear. The expression of high mobility group box chromosomal protein 1 in synovial membrane in patients with rheumatoid arthritis promotes synovial inflammatory expression. High mobility group box chromosomal protein 1 promotes the synthesis and release of inflammatory cytokines, pathological proliferation,apoptosis, autophagy and irreversible progression of phenotypic transformation in synovial fibroblasts in rheumatoid arthritis. In theory, it provides a new target for the clinical diagnosis and disease intervention of rheumatoid arthritis.