金贝痰咳清颗粒联合二羟丙茶碱治疗老年慢性支气管炎急性发作的效果

Effect of Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis

目的探讨金贝痰咳清颗粒联合二羟丙茶碱治疗老年慢性支气管炎急性发作的效果及安全性。方法选择2017年1月~2019年1月南充精神卫生中心(南充市第二人民医院)收治的慢性支气管炎急性发作期老年患者109例,依照随机数字表法将其分为对照组(54例)和观察组(55例)。对照组采用二羟丙茶碱治疗,观察组采用金贝痰咳清颗粒联合二羟丙茶碱治疗。两组均连续治疗2周,治疗后进行临床疗效评价。比较两组咳痰消失时间、咳嗽消失时间、啰音消失时间及喘息消失时间。比较两组治疗前后动脉血氧分压(PaO2)、血氧饱和度(SpO2)、动脉血二氧化碳分压(PaCO2)及血清白细胞介素(IL)-4、IL-6、肿瘤坏死因子-α(TNF-α)水平。记录两组治疗过程中不良反应的发生情况。结果观察组临床总有效率高于对照组,差异有统计学意义(P <0.05)。观察组咳痰、咳嗽、啰音及喘息消失时间均明显短于对照组,差异有统计学意义(P <0.05)。两组治疗后,PaCO2明显低于治疗前,PaO2、SpO2均明显高于治疗前,差异有统计学意义(P <0.05),同时观察组治疗后,PaO2、SpO2及PaCO2的变化幅度均明显大于对照组,差异有统计学意义(P <0.05)。两组治疗后血清IL-4、IL-6及TNF-α水平均明显比治疗前低,且观察组治疗后明显低于对照组,差异有统计学意义(P <0.05)。结论金贝痰咳清颗粒联合二羟丙茶碱治疗老年慢性支气管炎急性发作的临床效果显著,能够明显减轻临床症状,改善血气分析指标,降低炎性因子水平,且安全性较好。

Objective To explore clinical efficacy and safety of Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis. Methods From January 2017 to January 2019, 109 cases of elderly patients with acute exacerbation of chronic bronchitis in Nanchong Mental Health Center(the Second People′s Hospital of Nanchong City) were selected. According to the random number table method, they were divided into control group(n = 54) and observation group(n = 55). Patients of control group were treated with Diprophylline, while observation group were treated with Jinbei Tankeqing Particles combined with Diprophylline, both groups were treated for 2 weeks. Clinical curative effect was evaluated after treatment. The cough up phlegm, cough disappeared, then sound and wheezing disappeared times of the two groups were compared. The arterial partial pressure of oxygen(PaO2), oxyhemoglobin saturation(SpO2), partial pressure of carbon dioxide in artery(Pa CO2) and serum levels of interleukin(IL)-4, IL-6, tumor necrosis factor-α(TNF-α) of the two groups before and after treatment were com pared. The adverse reactions of the two groups were recorded. Results The total clinical effective rate of observation group was higher than that of control group, the difference was statistically significant(P < 0.05). The cough up phlegm,cough, then sound and wheezing disappeared times of observation group were significantly less than those of control group, the differences were statistically significant(P < 0.05). After treatment, the Pa CO2 of two groups were significantly lower than those before treatment, the PaO2, SaO2 of the two groups were significantly higher than those before treatment, the differences were statistically significant(P <0.05). And the PaO2, SaO2, Pa CO2 of observation group were significantly greater than those of control group, the differences were statistically significant(P < 0.05). After treatment, the serum levels of IL-4, IL-6, TNF-α of the two groups were significantly lower than before treatment, and those of observation group were lower than control group, the differences were statistically significant(P < 0.05). Conclusion Jinbei Tankeqing Particles combined with Diprophylline in the treatment of elderly patients with acute exacerbation of chronic bronchitis has a good efficacy and low adverse reactions. It can improve the clinical symptoms and blood gas analysis indexes, reduce the inflammatory factor levels.