阿莫西林克拉维酸钾联合阿奇霉素序贯疗法治疗社区获得性肺炎临床研究

A comparative study of amoxicillin and clavulanate potassium combined with azithromycin sequential therapy in the treatment of community acquired pneumonia

目的:研究阿莫西林克拉维酸钾联合阿奇霉素序贯疗法治疗社区获得性肺炎的效果。方法:2019年2月-2019年7月收治社区获得性肺炎患者96例,随机分为两组各48例。对照组给予阿莫西林克拉维酸钾联合阿奇霉素常规静脉给药治疗,观察组给予阿莫西林克拉维酸钾联合阿奇霉素序贯疗法治疗,两组疗程均为7~14 d。比较两组细菌学清除率、不良反应发生率及住院时间。结果:对照组治疗后不良反应发生率高于观察组,差异有统计学意义(P<0.05)。观察组平均住院时间显著低于对照组,差异有统计学意义(P<0.05)。两组细菌清除率比较,差异无统计学意义(P>0.05)。结论:阿莫西林克拉维酸钾联合阿奇霉素序贯疗法治疗社区获得性肺炎能够收到良好效果,且不良反应发生率低。

Objective:To explore the effect of amoxicillin and clavulanate potassium combined with azithromycin sequential therapy on community active pneumonia.Methods:96 cases of community-acquired pneumonia were selected from February 2019 to July 2019,they were randomly divided into the two groups with 48 cases in each group.The control group was given amoxicillin and clavulanate potassium combined with azithromycin.The experimental group was treated with amoxicillin and clavulanate potassium combined with azithromycin sequential therapy.The course of treatment in both groups was 7~14 days.The bacteriological clearance rate,incidence of adverse reactions and hospitalization time were compared between the two groups.Results:The incidence of adverse reactions in the control group was higher than that in the observation group,the difference was statistically significant(P<0.05).The average length of stay in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in bacterial clearance between the two groups(P>0.05).Conclusion:The sequential therapy of amoxicillin and clavulanate potassium combined with azithromycin can achieve good therapeutic effect,and the incidence of adverse reactions was low.