癫痫患者磷酸肌酸激酶同工酶亚型的鉴别及临床意义

Identification and clinical significance of phosphocreatine kinase isoenzyme subtypes in patients with epilepsy

目的:对癫痫患者升高的磷酸肌酸激酶及其同工酶亚型进行鉴别,研究其临床意义。方法:收治癫痫患者9例,对血液标本进行常规生化检查,对心肌酶升高标本进行电泳。同时随机选取健康人21例作为对照组。结果:CK值升高癫痫患者9例中电泳结果显示为CK-MM 7例,CK-MM值>97%,CK-MB值<3%,9例患者均未电泳出CK-BB。结论:通常骨骼肌中98%磷酸肌酸激酶组分为CK-MM亚型,心肌组织中有70%~80%为CK-MM亚型,CK-BB主要存在于脑组织。因此可认为癫痫患者肌酸激酶及其同工酶升高主要来自骨骼肌,大部分与癫痫患者心肌损伤及脑损伤不相关。

Objective:To identify the elevated creatine phosphokinase and its isoenzyme subtypes in epileptic patients and study their clinical significance.Methods:9 cases of blood samples from patients with epilepsy were collected and routine biochemical examinations were performed,electrophoresis of myocardial enzymes was performed.At the same time,21 healthy people were randomly selected as the control group.Results:Among the 9 epileptic patients with elevated CK,electrophoresis results showed that CK-MM was in 7 cases,CK-MM was>97%,CK-MB was<3%.CK-BB was not detected in 9 patients.Conclusion:98%creatine phosphokinase in skeletal muscle is usually classified as CK-MM subtype,70%~80%of them are CK-MM subtype in myocardial tissue,and CK-BB mainly exists in brain tissue.Therefore,it can be considered that the increase of creatine kinase and its isoenzymes in epilepsy patients mainly comes from skeletal muscle,and most of them are not related to myocardial injury and brain injury in patients with epilepsy.