肝硬化患者血小板压积的变化及意义

The changes and significance of platelet hematocrit in patients with liver cirrhosis

目的:探讨肝硬化患者血小板压积(PCT)检测的临床意义。方法:选取肝硬化患者4 308例作为观察组,同期选取健康体检者246例作为对照组。检测两组PCT水平,并分析PCT变化与肝硬化患者肝功能损害程度及并发症的关系。结果:观察组PCT显著低于对照组,差异有统计学意义(P<0.01)。观察组中肝硬化肝功能B级组PCT显著低于肝功能A级组,差异有统计学意义(P<0.01);肝功能C级组PCT显著低于肝功能A级组与B级组,差异有统计学意义(P<0.01)。肝硬化并发上消化道出血组PCT显著低于未并发上消化道出血组,差异有统计学意义(P<0.01);肝硬化并发肝性脑病组PCT显著低于未并发肝性脑病组,差异有统计学意义(P<0.01);肝硬化并发肝细胞癌组PCT显著高于未并发肝细胞癌组,差异有统计学意义(P<0.01)。结论:肝硬化患者PCT明显下降,并与肝功能损害程度及是否并发上消化道出血、肝性脑病、肝细胞癌等因素有密切关系。

Objective:To explore the clinical significance of platelet hematocrit(PCT)in patients with liver cirrhosis.Methods:4308 patients with cirrhosis were selected as the observation group,and 246 healthy subjects were selected as the control group.PCT was detected in the two groups,and the relationship between PCT changes and liver function damage and some complications was analyzed.Results:PCT in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.01).The PCT of the liver cirrhosis liver function grade B group was significantly lower than that of the liver function grade A group,the difference was statistically significant(P<0.01).The PCT of the liver function grade C group was significantly lower than that of the liver function grade A and B group,the difference was statistically significant(P<0.01).The PCT of cirrhosis with upper gastrointestinal hemorrhage group was significantly lower than that of the group without upper gastrointestinal hemorrhage,the difference was statistically significant(P<0.01).PCTP in the cirrhosis complicated with hepatic encephalopathy group was significantly lower than that in the without hepatic encephalopathy group,the difference was statistically significant(P<0.01).The PCT in the cirrhosis complicated with hepatocellular carcinoma group was significantly higher than that in the non-combined hepatocellular carcinoma group,the difference was statistically significant(P<0.01).Conclusion:The PCT of patients with cirrhosis is significantly decreased,and it is closely related to the degree of liver function damage in patients with liver cirrhosis and whether it is complicated by upper gastrointestinal hemorrhage,hepatic encephalopathy and hepatocellular carcinoma.