慢性阻塞性肺疾病急性加重期患者炎性标志物的研究进展

Research progress of inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease

慢性阻塞性肺疾病是一种常见的慢性呼吸系统疾病,其发生进展与气道慢性炎症有关。呼吸道感染引发急性加重,死亡率较高。现阶段,慢性阻塞性肺疾病急性加重期诊断主要依据临床症状,缺乏统一标准实验室指标,诊断的主观性强,容易造成漏诊或误诊,部分患者因综合治疗效果差而死亡。新型炎性标志物对慢性阻塞性肺疾病急性期患者的辅助诊断、病情与预后评估、用药指导及病情监测可起到指导作用,可作为新的治疗靶点进行深度研究。本文讨论慢性阻塞性肺疾病急性加重期患者炎性标志物的研究进展,旨在为进一步改善慢性阻塞性肺疾病急性加重期患者的存活率和生存质量提供依据。

Chronic obstructive pulmonary disease is a common chronic respiratory disease.Its occurrence and progression are related to chronic inflammation of the airway.Respiratory infections cause acute exacerbations and high mortality.At this stage,the diagnosis of acute exacerbation of chronic obstructive pulmonary disease is mainly based on clinical symptoms,lack of uniform standard laboratory indicators,and the subjective nature of the diagnosis is likely to cause missed diagnosis or misdiagnosis.Some patients die due to poor comprehensive treatment.The new inflammatory markers can play a guiding role in the auxiliary diagnosis,disease and prognosis evaluation,medication guidance and disease monitoring in patients with acute exacerbation of chronic obstructive pulmonary disease,and can be used as a new therapeutic target for in-depth study.This paper discuss the research progress of inflammatory markers in patients with acute exacerbation of chronic obstructive pulmonary disease,in order to provide evidence for further improvement of the survival rate and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease.