变异型伴中央颞区棘波儿童良性癫痫与锌及代谢相关激素的相关性

Correlation between variable benign epilepsy of childhood with centro-temporal spikes and zinc, metabolism-related hormones

目的探讨变异型伴中央颞区棘波的儿童良性癫痫(BECT)与锌及代谢相关激素的相关性。方法选取2009年1月~2017年12月南昌大学附属赣州医院收治的178例BECT患者作为研究对象,采用随机数字表法将其分为实验组(变异型BECT,58例)与对照组(典型BECT,120例)。比较两组的血微量元素及代谢相关激素水平,并分析锌与代谢相关激素的相关性。结果实验组锌、铁水平低于对照组,差异有统计学意义(P<0.05)。两组的铜水平比较,差异无统计学意义(P>0.05)。实验组的生长激素、皮质醇、甲状旁腺激素及促甲状腺素水平低于对照组,差异有统计学意义(P<0.05)。实验组的促肾上腺皮质激素、游离三碘甲状腺原氨酸、甲状腺素及25羟化维生素D水平高于对照组,差异有统计学意义(P<0.05)。线性相关分析提示,锌和甲状旁腺素成正相关(r=0.42,P<0.05),锌和促肾上腺皮质激素、生长激素及25羟化维生素D成负相关(r=-0.61、-0.49、-0.46,P<0.05),8种代谢相关激素中有12对显示正相关或负相关,在总的36对中占44%。结论锌及激素水平与变异型BECT密切相关,锌及激素的水平对判断变异型BECT的疗效及预后具有一定的临床意义。

Objective To investigate the correlation between variable benign epilepsy of childhood with centro-temporal spikes(BECT)and zinc,metabolism-related hormones.Methods A total of 178 children with benign epilepsy in Ganzhou Hospital affiliated to Nanchang University were chosen as the research objects from January 2009 to December 2017,they were divided into the experimental group(58 cases of variable BECT)and control group(120 cases of typical BECT)via the random number table method.The levels of blood trace element and metabolism-related hormones were compared between the two groups,and the correlation between zinc and metabolism-related hormones was analyzed.Results The levels of zinc and ferrum in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in cuprum level between the two groups(P>0.05).The levels of growth hormones,cortisol,parathyroid hormones and thyrotropin in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of corticotrophin,freetriiodthyronine,free thyroxine and 25 hydroxylated vitamin D in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).Linear correlation analysis indicated that zinc was positively correlated with parathyroid hormone(r=0.42,P<0.05),zinc was negatively correlated with corticotrophin,growth hormones,and 25 hydroxylated vitamin D(r=-0.61,-0.49,-0.46,P<0.05),twelve of the eight metabolism-related hormones showed positive or negative correlations,accounting for 44%of the total 36 pairs.Conclusion Variable benign epilepsy and the disorder of the levels of zinc and hormones could be closely related,serum zinc and hormones levels have certain clinical value in preventing and treating variable benign epilepsy.