糖化血红蛋白指数与2型糖尿病周围神经病变的相关性研究

Relationship between haemoglobin glycation index and risk of diabetic peripheral neuropathy in patients with type 2 diabetes

目的探讨2型糖尿病(T2DM)患者糖化血红蛋白指数(HGI)与糖尿病周围神经病变(DPN)发病的关系。方法选取2016年1月—2017年12月在扬州大学临床医学院内分泌科住院的726例T2DM患者的临床资料。根据空腹血糖(FPG)与糖化血红蛋白(HbA1c)建立线性回归方程并计算HGI;根据HGI数值,采用三分位法将患者分为低HGI组、中HGI组及高HGI组,比较3组健康状况差异,并分析HGI与DPN发病的相关性。结果3组患者年龄、体重指数、收缩压、舒张压、平均动脉压、空腹C肽、FPG、HbA1c、总胆固醇及血尿酸比较,差异有统计学意义(P<0.05)。高HGI组患者发生DPN的风险是低HGI组的1.773倍(P<0.05)。Logistic回归分析显示,年龄[OR=1.011(95%CI:1.003,1.019)]、糖尿病病程[OR=1.091(95%CI:1.040,1.145)]及HGI[OR=1.259(95%CI:1.006,1.574)]是DPN发生的危险因素。结论HGI可作为预测T2DM患者发生DPN风险的指标之一。

Objective To explore the relationship between haemoglobin glycation index(HGI)and risk of diabetic peripheral neuropathy(DPN)in patients with type 2 diabetes(T2DM).Methods The clinical characteristics of 726 cases of hospitalized patients with T2DM were collected.A linear regression equation was used to calculate HGI according to the relationship between FPG and HbA1c.According to the HGI value,all the subjects were divided into low HGI group,middle HGI group and high HGI group.The clinical data were compared among the three groups and the correlation between HGI levels and the prevalence of DPN was analyzed.Results There were significant differences in age,BMI,SBP,DBP,MBP,Fasting C-peptide,FPG,HbA1c,TC and SUA among the three groups(P<0.05).The prevalence risks of DPN were 1.773 times in high HGI group more than in low HGI group(P<0.05).Logistic regression analysis showed that age(OR=1.011,95%CI:1.003,1.019),diabetes duration(OR=1.091,95%CI:1.040,1.145)and HGI(OR=1.259,95%CI:1.006,1.574)were risk factors for DPN.Conclusions HGI may be used as one of the risk predictor of DPN in patients with T2DM.