非痴呆帕金森病患者眼区面孔情绪认知功能与事件相关电位P300的相关性分析

Correlation between facial cognition function and event-related potential P300 in patients with non-dementia Parkinson disease

目的通过对非痴呆帕金森病(PD)患者眼区面孔情绪识别功能和事件相关电位P300检测,探讨非痴呆PD患者面孔情绪认知功能损害的特点,以及情绪识别与P300潜伏期和波幅的相关性。方法选取2016年8月—2018年6月于安徽医科大学附属巢湖医院神经内科确诊的非痴呆PD患者28例作为非痴呆PD组,选取同期该院健康体检者32例作为对照组。应用眼区面孔情绪识别测验和P300检测,观察喜、惊、恐、悲、厌及怒的识别得分,以及P300潜伏期和波幅,并比较6种情绪识别得分与P300潜伏期和波幅的相关性。结果与对照组比较,非痴呆PD组在恐、悲及厌的情绪面孔识别得分较对照组低(P<0.05),非痴呆PD组P300潜伏期较对照组长(P<0.05),波幅较对照组低(P<0.05);P300潜伏期与恐、悲、厌及怒得分呈负相关(r=-0.718、-0.614、-0.818和-0.829,P<0.05),P300波幅与悲、厌及怒得分呈正相关(r=0.824、0.928和0.621,P<0.05)。结论非痴呆PD患者存在眼区面孔情绪认知功能损害,以恐、悲及厌负性面孔情绪认知损害为主,进一步证实了基底节参与情绪认知加工的假说;P300与面孔情绪识别得分具有良好的相关性,P300潜伏期和波幅是反映早期非痴呆PD患者情绪认知功能障碍的敏感指标。

Objective To explore the characteristics of facial emotion recognition function impairment in PD patients,and the correlation between emotion recognition and P300 latency and amplitude through the detection of facial emotion recognition function and event-related potential P300 in non demented Parkinson disease(PD)patients.Methods A total of 28 cases of early non-dementia PD patients(PD group)and 32 cases of healthy physical examination(HC group)were selected.The eye area emotion recognition test and P300 test were applied to observe the recognition scores of the six basic emotions(joy,surprise,terror,sorrow,disgust and anger),as well as P300 latency and amplitude.The correlation of the six emotion recognition scores with the P300 latency and amplitude were compared.Results Compared with the HC group,the scores of the emotional face recognition of the“terror”,“sorrow”and“disgust”in the PD group were lower than those in the control group(P<0.05);P300 latency in PD group was prolonged(P<0.05),and amplitude was decreased(P<0.05);P300 latency were negatively correlated with“terror”(r=-0.718,P<0.05),“sorrow”(r=-0.614,P<0.05),“disgust”(r=-0.818,P<0.05),“angry”(r=-0.829,P<0.05)scores,and P300 amplitude were positively correlated with“sorrow”(r=0.824,P<0.05),“disgust”(r=0.928,P<0.05),and“angry”(r=0.621,P<0.05)scores.Conclusions PD patients have damage in the eye area emotional cognition,and impairment of the face emotion recognition are mainly based on“terror”,“sorrow”and“disgust”negative facial emotions,further confirming the hypothesis that the basal ganglia participates in emotional cognition processing;P300 and face emotion recognition scores have good correlation,and P300 latency and amplitude are reflected as sensitive indicators for emotional cognitive impairment of early Parkinson disease patients without dementia.