不同剂量质子泵抑制剂在消化性溃疡出血中的效果

Effect of Different Doses of Proton Pump in Peptic Ulcer Bleeding

目的研究消化性溃疡出血治疗中质子泵抑制剂不同给药剂量的效果。方法选择本医院接受治疗的消化性溃疡出血患者作为本次研究的研究对象,根据其入院顺序对将58例消化性溃疡出血患者进行分组,主要包括两组,其中观察组实施大剂量质子泵抑制剂治疗;对照组实施小剂量质子泵抑制剂治疗,将两组住院时间、止血时间、治疗效果和不良反应情况进行对比。结果观察组消化性溃疡出血患者住院时间、止血时间与对照组相比较,具有统计学差异(P <0.05)。两组之间的治疗有效率存在差异,差异具有统计学意义(P <0.05),观察组消化性溃疡出血患者不良反应发生率与对照组相比较,具有统计学差异(P <0.05)。结论应用剂量为120 mg的奥美拉唑治疗消化性溃疡出血,效果相比小剂量更佳,且安全性极高,值得研究和推广。

Objective To study the effect of different dosage of proton pump inhibitor in the treatment of peptic ulcer bleeding. Methods 58 patients with peptic ulcer bleeding were divided into two groups according to the order of admission. The observation group was treated with high-dose proton pump inhibitor, while the control group was treated with low-dose proton pump inhibitor. The hospitalization time, hemostasis time, treatment effect and adverse reactions of the two groups were compared. Results Compared with the control group, the time of hospitalization and hemostasis in the observation group were significantly different(P<0.05). There was significant difference between the two groups(P<0.05). The incidence of adverse reactions in the observation group was significantly different from that in the control group(P<0.05). Conclusion Omeprazole with a dose of 120 mg is more effective and safe in the treatment of peptic ulcer bleeding than that with a small dose.