基于骨肉不相亲理论探讨低频脉冲电磁场联合腰背肌训练对糖尿病性骨质疏松患者IL-6及TNF-α的影响

Effect of low frequency pulsed electromagnetic field combined with lumbar dorsal muscle training based on the theory of disharmony between bone and muscle in IL-6,TNF-α

目的:观察低频脉冲电磁场(PEMFs)联合腰背肌训练对糖尿病性骨质疏松中医证候积分及IL-6、TNF-α的影响。方法:选取2型糖尿病骨质疏松患者64例,随机分为两组,联合组及对照组,两组基础治疗均给予左归丸口服,联合组在此基础上给予PEMFs联合腰背肌训练,对照组仅予基础治疗,观察不同治疗方法对两组中医证候积分以及IL-6及TNF-α的影响。结果:联合组经PEMFs联合腰背肌训练后,症状改善明显,中医证候积分较前降低,总有效率93.75%,较对照组37.5%有统计学差异。联合组治疗后TNF-α、IL-6[(8.16±0.63)pg/ml、(4.29±0.32)pg/ml]较治疗前降低[(9.36±0.32)pg/ml、(4.70±0.51)pg/ml],组内及组间比较均有明显统计学意义。结论:炎症参与2型糖尿病骨质疏松的进程,PEMFs联合腰背肌训练对骨代谢有保护作用,结合中医理论基础,更好地确证了"骨肉不相亲"的科学内涵。

Objective:To observe the effect of pulsed electromagnetic field(PEMFs) combined with lower back muscle training on the level of IL-6 and TNF-α in patients with diabetic osteoporosis. Methods:64 patients with diabetic osteoporosis were divided into two groups,combination group and control group,Zuogui pills were given to 2 groups,combination group also combination of PEMFs and lower back muscle training. To evaluate the two groups of the levels of IL-6,TNF-α and the TCM syndrome points. Results:After combination of PEMFs and lower back muscle training,the syndrome scores of TCM were obviously improved compared with the previous,the total efficiency 93.75% vs 37.5% of control group. After the treatments,TNF-α、IL-6[(8.16±0.63) pg/ml、(4.29±0.32) pg/ml]were lower than before[(9.36±0.32) pg/ml、(4.70±0.51)pg/ml] in the combination group.There were statistically decreased compared with before and between groups. Conclusion:The process of osteoporosis in cases with type 2 diabetes may involve in inflammation,PEMFs combined with lower back muscle training play a protective role on bone metabolism,given the theoretical basis of TCM,it’s more conclusive for the scientific implication of disharmony between bone and muscle.