胶质母细胞瘤信号通路的研究

Study on Glioblastoma Signaling Pathway

胶质母细胞瘤(GBM)是胶质瘤中恶性程度最高的脑部肿瘤,其死亡率和复发率较高。目前GBM发生发展机制尚不明确,无特效治疗手段。常见的治疗方法有手术切除、放疗及化疗等,但其预后差,因此寻找GBM相关信号通路可为了解其发病机制、靶向治疗提供指引。目前,研究发现p53途径、MAPK途径、PI3K/AKT途径以及Notch途径是参与GBM的重要通路;除此之外,还有其他的信号通路也陆续被发现。本文通过对p53信号通路、MAPK信号通路、PI3K/AKT信号通路、Notch信号通路以及其他信号通路在GBM中的作用进行综述,旨在为临床治疗GBM提供参考。

Glioblastoma(GBM)is the most malignant brain tumor in glioma,with a high mortality and recurrence rate.At present,the mechanism of development of GBM is still unclear,and there is no specific treatment.Common treatment methods include surgical resection,radiotherapy and chemotherapy,but its prognosis is poor.Therefore,finding a signal pathway related to GBM can provide guidance for understanding its pathogenesis and targeted therapy.At present,the study found that the p53 pathway,MAPK pathway,PI3K/AKT pathway and Notch pathway are important pathways involved in GBM;in addition,other signaling pathways have been discovered.This article reviews the role of p53 signaling pathway,MAPK signaling pathway,PI3K/AKT signaling pathway,Notch signaling pathway and other signaling pathways in GBM,aiming to provide reference for clinical treatment of GBM.