艾地苯醌辅助治疗急性脑梗死后运动性失语的研究

Study on Idebenone as Adjuvant Treatment for Motor Aphasia after Acute Cerebral Infarction

目的观察艾地苯醌辅助治疗急性脑梗死后运动性失语的临床疗效。方法选取2018年3月~2019年3月我院收治的急性脑梗死后运动性失语患者60例为研究对象,采用随机数字表法分为观察组和对照组,各30例。对照组给予常规综合治疗,观察组在对照组基础上给予艾地苯醌治疗。比较两组临床治疗总有效率、失语改善程度、语言功能(自发语言、阅读能力、复述、命名)评分以及临床不良反应发生情况。结果观察组治疗总有效率为80.00%,高于对照组的60.00%,差异有统计学意义(P<0.05);治疗后观察组失语程度改善优于对照组,差异有统计学意义(P<0.05);两组自发语言、阅读能力、复述、命名评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);在治疗和观察期间,两组均未发生严重不良反应。结论艾地苯醌辅助治疗急性脑梗死后运动性失语患者效果确切,可有效改善患者的失语症状,提高语言功能,具有临床应用的重要价值。

Objective To observe the clinical effect of Idebenone in the adjuvant treatment of motor aphasia after acute cerebral infarction.Methods 60 patients with motor aphasia after acute cerebral infarction treated in our hospital from March 2018 to March 2019 were selected as the research subjects,and the random number table method was used to divide them into observation group and control group,30 cases each.The control group was given conventional comprehensive treatment,and the observation group was given idebenone on the basis of the control group.The total effective rate of clinical treatment,improvement of aphasia,scores of language function(spontaneous language,reading ability,repetition,naming)and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 80.00%,which was higher than 60.00%in the control group,the difference was statistically significant(P<0.05).After treatment,the improvement of the aphasia in the observation group was better than that of the control group,the difference was statistically significant(P<0.05);After treatment,the spontaneous language,reading ability,repetition,and naming scores of the two groups were higher than before the treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);during the treatment and observation period,both groups were no serious adverse reactions occurred.Conclusion Idebenone is effective in adjuvant treatment of patients with motor aphasia after acute cerebral infarction.It can effectively improve the symptoms of aphasia and improve language function.It has important value in clinical application.