持续泵入奥曲肽治疗重症胰腺炎的疗效观察

Therapeutic Effect of Continuous Pumping of Octreotide on Severe Pancreatitis

目的研究持续泵入奥曲肽治疗重症胰腺炎的疗效及安全性。方法选择2018年2月~2019年2月在我院诊治的重症胰腺炎患者84例,采用随机数字表法分为对照组和观察组,各42例。对照组给予前列地尔治疗,观察组在对照组基础上持续泵入奥曲肽。比较两组治疗总有效率、临床症状(腹痛、腹胀、恶心呕吐)消失时间、临床体征(胰腺水肿、血淀粉酶、尿淀粉酶、白细胞)恢复时间以及不良反应发生率。结果观察组总有效率为95.23%,高于对照组的83.33%,差异有统计学意义(P<0.05);观察组临床腹痛、腹胀、恶心呕吐症状消失时间均短于对照组,差异有统计学意义(P<0.05);观察组胰腺水肿改善、血淀粉酶恢复、尿淀粉酶恢复、白细胞恢复时间均短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为4.76%,低于对照组的16.67%,差异有统计学意义(P<0.05)。结论持续泵入奥曲肽治疗重症胰腺炎临床疗效确切,可快速改善临床症状和体征,促进血尿淀粉酶恢复,且不良反应少,安全性良好。

Objective To study the efficacy and safety of continuous pumping of octreotide in the treatment of severe pancreatitis.Methods 84 patients with severe pancreatitis who were treated in our hospital from February 2018 to February 2019 were enrolled.The patients were divided into the control group and the observation group by random number table,42 cases each.The control group was treated with alprostadil,and the observation group continued to pump octreotide on the basis of the control group.The total effective rate,clinical symptoms(abdominal pain,bloating,nausea and vomiting)disappeared,clinical signs(pancreatic edema,blood amylase,urinary amylase,white blood cells)recovery time and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.23%,which was higher than that of the control group 83.33%,the difference was statistically significant(P<0.05).The clinical symptoms of abdominal pain,abdominal distension and nausea and vomiting were shorter than the control group,the difference was statistically significant(P<0.05);the improvement of pancreatic edema,blood amylase recovery,urinary amylase recovery,and white blood cell recovery time in the observation group were shorter than the control group,the difference was statistically significant(P<0.05);The incidence of adverse reactions in the observation group was 4.76%,which was lower than that in the control group 16.67%,the difference was statistically significant(P<0.05).Conclusion The continuous clinical efficacy of octreotide in the treatment of severe pancreatitis can improve the clinical symptoms and signs,promote the recovery of hematuria and amylase,and have fewer adverse reactions and good safety.