神经生长因子对牙周炎犬即刻种植骨结合影响的实验研究

Experimental Study on the Effect of Nerve Growth Factor on Immediate Bone Grafting in Periodontitis Dogs

目的探究神经生长因子对牙周炎犬即刻种植骨结合的影响。方法于2018年5月-2019年4月以46例牙周炎犬为研究对象,采用随机分组的方法将其分为对照组和观察组,每组23例,其中观察组注射神经生长因子进行治疗,对照组注射相同体积的生理盐水,对两组种植体骨结合率和并发症发病率进行比较。结果对照组牙周炎犬术后种植体骨结合率为(57.26±5.13)%,远低于观察组的(86.51±8.94)%,两组数据差异有统计学意义(t=5.246,P=0.013);观察组术后并发症发病率为4.35%,远低于对照组的26.09%,组间数据差异有统计学意义(χ~2=7.673,P=0.009)。结论通过对牙周炎犬注射神经生长因子进行治疗,不仅可以提高种植体骨结合率,还可以降低术后并发症发病率,具有一定的临床研究意义。

Objective To investigate the effect of nerve growth factor on immediate bone grafting in periodontitis dogs. Methods Forty-six cases of periodontitis dogs from May 2018 to April 2019 were randomly divided into control group and observation group. Each group had 23 cases, of which observation group Nerve growth factor was injected for treatment, and the same volume of normal saline was injected into the control group to compare the osseointegration rate and the incidence of complications between the two groups. Re-sults The postoperative implant osseointegration rate of the control group of periodontitis dogs was(57.26 ±5.13)%, which was much lower than that of the observation group(86.51±8.94)%. The difference between the two groups was statistically significant(t=5.246, P=0.013). Academic significance;the incidence of postoperative complications in the observation group was 4.35%, which was much low-er than that of the control group of 26.09%. The data between the groups were significantly different, which was statistically significant(χ~2=7.673, P=0.009). Conclusion The treatment of periodontitis in dogs with nerve growth factor can not only improve the osseointegra-tion rate of implants, but also reduce the incidence of postoperative complications. It has certain clinical significance.