卡前列素氨丁三醇联合缩宫素预防高危妊娠剖宫产术中出血的效果分析

Analysis of Effect of Carboprost Tromethamine and Oxytocin in Prevention of Intraoperative Bleeding of High-risk Pregnancy with Cesarean Section

目的探讨卡前列素氨丁三醇联合缩宫素预防高危妊娠剖宫产术中出血的效果。方法选取2017年1月-2018年6月期间于该院拟行剖宫产分娩的92例高危妊娠产妇,利用随机数表法分为两组,各46例。对照组采用缩宫素注射液干预,观察组采用缩宫素注射液+卡前列素氨丁三醇干预,对比两组临床疗效、出血量、临床相关指标及不良反应。结果较对照组(78.26%),观察组治疗总有效率(93.48%)更高,差异有统计学意义(χ~2=4.390,P=0.365);观察组术中、术后2 h及术后2~24 h出血量[(348.17±162.58)mL、(48.47±21.25)mL、(22.39±9.26)mL],较对照组[(452.26±173.69)mL、(75.82±32.53)mL、(31.94±10.48)mL]少,差异有统计学意义(t=2.967、4.774、4.632,P=0.004、0.000、0.000);观察组止血起效时间、住院时间[(9.64±3.57)min、(6.74±1.05)d]较对照组[(16.53±3.68)min、(8.37±1.18)d]短,宫缩持续时间[(2.79±0.54)h]较对照组[(2.12±0.46)h]长,差异有统计学意义(t=9.114、6.999、6.406,P=0.000、0.000、0.000);观察组不良反应发生率(17.39%)与对照组(15.22%)相比,差异无统计学意义(χ~2=0.080,P=0.778)。结论卡前列素氨丁三醇联合缩宫素用于高危妊娠剖宫产术中止血效果显著,可有效减少术中及术后出血量,缩短止血起效时间,促进产妇恢复,且具有较高安全性。

Objective To study the effect of carboprost tromethamine and oxytocin in prevention of intraoperative bleeding of high-risk pregnancy with cesarean section. Methods 92 cases of high-risk pregnant women with cesarean section from January 2017 to June2018 were divided into two groups by random number table, with 46 cases in each group. Control group took oxytocin injection, ob-servation group took oxytocin injection and carboprost tromethamine. Clinical efficacy, bleeding volume, clinical indexes, adverse re-actions were compared. Results The effective rate of observation group(93.48%) was higher than that of control group(78.26%)( χ~2=4.390, P=0.365);The intraoperative, postoperative 2 h, 2~24 h bleeding volume in observation group [(348.17 ±162.58)mL,(48.47±21.25)mL,(22.39±9.26)mL] were less than those in control group [(452.26±173.69)mL,(75.82±32.53)mL,(31.94±10.48)mL](t=2.967,4.774, 4.632, P=0.004, 0.000, 0.000);The onset time of hemostasis and hospital stays in observation group [(9.64 ±3.57)min,(6.74±1.05)d] were shorter than those in control group [(16.53±3.68)min,(8.37±1.18)d], and the duration of uterine contraction in observation group [(2.79±0.54)h] was longer than that in control group [(2.12 ±0.46)h](t=9.114, 6.999, 6.406, P=0.000, 0.000, 0.000);There was no statistical difference in the adverse reactions between observation group(17.39%) and control group(15.22%)( χ~2=0.080, P=0.778).Conclusion Carboprost tromethamine and oxytocin in intraoperative hemostasis is effective, it can reduce intraoperative and postopera-tive bleeding volume, shorten hemostasis time, and promote maternal recovery, which has higher safety.