PRR11在食管癌中的表达及临床意义

Expression of PRR11 in Esophageal Squamous Cell Carcinoma and Clinical Significance

目的研究富含脯氨酸蛋白11(proline-rich protein 11,PRR11)在食管癌组织中的表达及临床意义。方法采用免疫组织化学法检测80例食管癌组织及其对应癌旁组织中PRR11蛋白的表达,并用荧光定量PCR检测PRR11在食管癌及其癌旁组织中的表达,分析其与临床病理特征之间的关系。结果PRR11在食管鳞状细胞癌组织中的阳性表达率为63.8%(51/80),高于癌旁组织的18.8%(15/80),差异有统计学意义(P<0.001)。荧光定量PCR结果发现,PRR11在食管鳞状细胞癌组织中的表达高于癌旁组织,差异有统计学意义(P<0.05)。PRR11蛋白高表达与肿瘤分化程度、TNM分期及淋巴结转移相关,各组间表达差异有统计学意义(P<0.05)。结论PRR11在食管癌组织中表达升高,可为食管癌的预后、诊断提供参考。

Objective To explore the expression of PRR11 and its clinical significance in esophageal squamous cell carcinoma(ESCC).Methods Expression of PRR11 in 80 ESCC samples was detected by immunohistochemical method,and qRT-PCR was used to detect the expression of PRR11 in ESCC and its adjacent tissues.The correlation between PRR11 expression and clinical pathological features was also analyzed.Results The positive expression rate of PRR11 in ESCC,63.8%(51/80)was higher than that in adjacent tissues 18.8%(15/80),which was a statistically significant difference(P<0.001).PRT-PCR analysis showed that the expression of PRR11 in ESCC was higher than that in it adjacent tissues(P<0.05).PRR11 over expression was significantly associated with tumor differentiation,TNM stage and lymph node metastasis(P<0.05).Conclusion The elevation of PRR11 expression can provide some reference to the prognosis and diagnosis of ESCC.