骨质疏松骨折史和合并症对健康相关生活质量的影响

The impact of osteoporosis fracture history and complications on health-related quality of life

目的 观察骨质疏松骨折史和合并症对健康相关生活质量(HRQOL)的影响。 方法 基于2013年至2018年获得的5年数据。使用双能X射线吸收法测量骨密度,在2078名调查参与者中诊断出骨质疏松症。根据骨质疏松症诊断标准 T 评分≥-1.0被认为骨密度正常, T 评分-1^-2.5为骨量减少,而 T 评分<-2.5为骨质疏松症。EuroQol五维问卷(EQ-5D)指数评分用于评估生活质量。 结果 在2078例被诊断患有骨质疏松症的患者中,发现骨折发生率为11.02%。手腕骨折最常见,为4.52%,男性和女性患病率差异有统计学意义 ( P <0.001)。骨质疏松症患者的EQ-5D指数评分为0.84±0.01。除癌症外,与没有相关疾病的患者相比,患有骨关节炎、类风湿关节炎、高血压、糖尿病、慢性阻塞性肺病和心血管事件的患者的EQ-5D指数评分显著降低。 结论 发现低HRQOL评分与先前的脊柱骨折和骨质疏松症患者的合并症有关,且经历多次骨折的骨质疏松症患者HRQOL严重下降。

Objective To observe the effects of osteoporosis fracture history and complications on health-related quality of life (HRQOL). Methods This study was based on 5-year-data obtained from 2013 to 2018. Osteoporosis was diagnosed in 2078 survey participants according to their bone mineral density measurements using dual energy X-ray absorptiometry. According to the World Health Organization study group, T-scores at or above -1.0 are considered as normal, those between -1.0 and -2.5 as osteopenia, and those at or below -2.5 as osteoporosis. The EuroQol five-dimensional questionnaire (EQ-5D) index score was used to assess the QOL. Results Of 2078 patients diagnosed with osteoporosis, incidence of fracture was 11.02%. Wrist fractures were the most frequent, affecting 4.52% of the patients. The incidence between men and women was significantly different ( P <0.001). The overall EQ-5D index score was 0.84±0.01 in patients with osteoporosis. Except of cancer, the EQ-5D index score was significantly lower in those with osteoarthritis, rheumatoid arthritis, hypertension, diabetes, chronic obstructive pulmonary disease, and cardiovascular events than those without any related diseases. Conclusion We found that low HRQOL is associated with previous spine fracture and complications in patients with osteoporosis. Multiple fracture experiences greatly deteriorate HRQOL in patients with osteoporosis.