骨骼内分泌激素与糖尿病代谢相关性研究进展

Research progress on the relationship between bone hormones and diabetes

骨骼是一种内分泌器官,其分泌的多种激素与糖尿病的关系成为最新研究热点,如成骨细胞分泌的骨钙素(osteocalcin,OC)具有刺激胰岛β细胞增殖、促进胰岛素的生成、上调脂肪组织中脂联素(adiponectin,APN)的表达等功能,从而增加能量释放、改善糖脂代谢以及调节脂肪含量。最新发现脂质运载蛋白-2(lipocalin 2,LCN2)可在成骨细胞中分泌,其与肥胖、高血糖、胰岛素抵抗等代谢紊乱密切相关,并通过作用于大脑神经元来影响食欲。以上发现揭示了新的能量平衡调节机制,此类内分泌激素有可能成为糖尿病发生风险的预测因子,并可能为其治疗提供新靶点。

Bone has recently been found to be an endocrine organ,which has led to many investigations on the relationship between bone hormones and diabetes.For example,osteocalcin(OC)secreted by osteoblast could not only stimulate beta cells’expression and promote their proliferation,but also increase the expression of adiponectin(APN)in the adipose tissues.Moreover,OC can increase energy release,improve glycolipid metabolism,as well as regulate fat content.It was newly found that lipocalin2(LCN2),highly expressed in adipose tissues,can be secreted by osteoblasts and is closely related to obesity,high blood glucose,insulin resistance and other metabolic disorders.In addition,researchers have found that LCN2 can act on brain neurons and affect one’s appetite.These discoveries reveal a new mechanism of energy-balance regulation,which may be a predictor of diabetes risk and provide a new target for treatment.