摘要
2型糖尿病(type 2 diabetes mellitus,T2DM)通过多种因素影响骨微结构和骨密度,导致骨强度下降,骨折风险增加。定量CT(quantitative computed tomography,QCT)测定三维体积骨密度(volume bone mineral density,vBMD)优于双能X线吸收法(dual energy X-ray absorptiometry,DXA)测定的面积骨密度(area bone mineral density,aBMD)对T2DM患者骨折风险评估,还能发现松质骨的结构改变、皮质骨多孔性结构,对骨量细微改变具有高敏感性。将QCT与有限元分析法结合,通过骨密度、骨组织结构同时分析骨应力来评价骨强度,对T2DM患者骨折风险的预测更有价值。
Type 2 diabetes mellitus (T2DM) affects bone micro-architecture and bone mineral density (BMD) via many clinical factors, leading to decreased bone strength and increased fracture risk. Quantitative computed tomography (QCT) measures three dimensional volume bone mineral density (vBMD), and is superior to area BMD (aBMD) measured by dual energy X-ray absorptiometry (DXA) in assessing the fracture risk of T2DM patients. QCT also detects the structure of the cortical and cancellous bones, and is highly sensitive to slight changes in bone microarchitecture. Combination of QCT and QCT-based finite element method (QCT-based FEM) will be valuable for predicting fracture risk in patients with T2DM by integrated analysis of BMD, bone structure, and bone stress.
作者
谭璐
闫彩凤
TAN Lu;YAN Caifeng(The second Xiangya Hospital of Central South University,Changsha 410000,China;Department of Endocrinology,Northern Jiangsu People’s Hospital,Yangzhou 225001,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2019年第11期1641-1644,共4页
Chinese Journal of Osteoporosis
基金
江苏省扬州市重点研发计划(社会发展项目)(YZ2016061)
关键词
定量CT
2型糖尿病
骨质疏松
有限元分析法
quantitative computed tomography(QCT)
type 2 diabetes mellitus(T2DM)
osteoporosis
finite element method(FEM)
