妊娠哺乳相关性骨质疏松症的研究进展

The research progress in pregnancy and lactation-associated osteoporosis

妊娠哺乳相关性骨质疏松症(pregnancy and lactation-associated osteoporosis,PLO)是指发生于妊娠和哺乳期,以低骨量和骨组织微结构破坏为特征,骨质脆性增加和易于骨折的全身性骨代谢性疾病。由于PLO发病率低,医师重视程度不够,常常容易被漏诊或误诊。目前PLO的病理生理机制尚未完全明确,研究报道也多以个案或病例报道为主,尚无统一治疗方案。本文就妊娠哺乳相关性骨质疏松症的发病机制和治疗进展等方面作一综述。

Pregnancy and lactation-associated osteoporosis(PLO)is a systemic bone metabolic disease,characterized by low bone mass and microstructural destruction of bone tissue that increase bone fragility and prone to fracture during pregnancy and lactation.Due to the low incidence of PLO,the doctors do not pay enough attention to it,leading to misdiagnosis or underdiagnosis.At present,the pathophysiological mechanism of PLO has not been completely clarified.The reports are mostly based on individual case or case reports.There is no unified treatment plan yet.This article reviews the research progress in the pathogenesis and treatment of PLO.