贵阳地区5151例医院就诊女性HPV感染亚型分析

Analysis of the subtypes of HPV infection in 5151 hospital females in Guiyang District

目的了解贵阳地区女性的人乳头瘤病毒(HPV)感染的流行病学特征,为本地区宫颈癌重点人群的筛查、随访及宫颈HPV疫苗的开发及临床应用提供理论依据。方法选取2018年5月至11月在贵州省人民医院就诊、行HPV分型检查的5151例女性为研究对象,采用微流控芯片技术对HPV进行分析检测,分析不同年龄组HPV的感染情况。结果本研究5151例女性中有1484例女性HPV检测阳性,总阳性率为28.81%。HPV分型检测结果显示,单一型HPV感染率为20.27%(1044/5151),感染率排名前3位的HPV优势亚型是HPV52、16和58。多重型HPV感染率为8.54%(440/5151),二重感染最常见,其中以HPV52与HPV51共感染最为多见。结论贵阳地区女性HPV感染率偏高,以单一型感染为主,最常见的感染亚型是高危型HPV52、16和58;多重型HPV感染以HPV52与HPV51共感染的二重感染最常见,且单一型和多重型HPV感染有各自的年龄分布特点,在该地区感染预防工作中应给予足够重视。

Objective To analyze the subtypes of HPV infection in 5151 hospital females in Guiyang District,and to provide theoretical foundations for Screening and follow-up for cervical cancer patients and development and clinical application of HPV vaccine.Methods The detection results of 5151 women who admitted to the People′s Hospital of Guizhou and detected HPV typing examination from May to December 2018 were enrolled in the study,to investigate the subtypes of HPV infection in different age groups.Results 1484 out of 5151 women were HPV positive,and the positive rate of HPV infection was 28.81%.The detection results of subtypes of HPV infection indicated that the positive rate of single HPV type infection was 20.27%(1044/5151),at the same time,multiple HPV subtypes infection was 8.54%(440/5151).The most population subtypes in single HPV type infection were HPV52,16 and 58,meanwhile double HPV subtypes infection was the most common form in multiple HPV subtypes infection.Conclusion The total infection rate of HPV in Guiyang District is high,which mainly caused by single HPV type infection.The most population subtypes of HPV infection were HPV52,16 and 58.The co-infection of HPV52 and HPV51 is the most common multiple HPV subtypes infection.The single and multiple HPV infections have their own age distribution characteristics.It is necessary to focus on preventing these high-risk HPV infection of females in this area.