COPD患者血清降钙素原、前清蛋白及C反应蛋白水平变化及其临床意义

Changes of serum calcitonin,prealbumin and hypersensitive C-reactive protein levels in patients with chronic obstructive pulmonary disease and their clinical significance

目的探讨慢性阻塞性肺疾病患者降钙素原(PCT)、前清蛋白(PA)、C反应蛋白(CRP)水平变化及其临床意义。方法选取2016年10月至2018年3月该院收治的肺疾病患者180例为该研究对象,根据疾病类型的不同将所有患者分为两组,对照组为非慢性阻塞性肺疾病患者(n=60),直接采用抗菌药物治疗;研究组为慢性阻塞性肺疾病患者(n=120),将研究组分为研究组A(n=60)和研究组B(n=60),研究组A直接采用抗菌药物治疗,研究组B根据检测指标调整使用抗菌药物治疗。对比两组PCT、PA、CRP水平、不良反应及肺功能。结果研究组血清PCT、PA及CRP显著高于对照组(P<0.05);治疗前研究组A患者第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)与研究组B比较差异无统计学意义(P>0.05),治疗后研究组B的FEV1、FEV1/FVC均显著高于研究组A(P<0.05);经治疗后研究组B的血清PCT、PA及CRP明显低于研究组A(P<0.05);研究组B不良反应发生率明显低于研究组A(P<0.05)。结论在慢性阻塞性肺疾病患者治疗过程中,血清降钙素原、前清蛋白及C反应蛋白水平会随患者肺功能指标的改善而发生变化,对于指导临床抗菌治疗具有一定的意义。

Objective To investigate the changes of procalcitonin(PCT),prealbumin(PA)and C-reactive protein(CRP)levels in patients with COPD and their clinical significance.Methods From October 2016 to March 2018,180 patients with pulmonary diseases in the hospital were enrolled in the study.According to the different types of diseases,all patients were divided into two groups.The control group was non-chronic obstructive pulmonary disease patients(n=60),who were directly treated with antibiotics.The study group was chronic obstructive pulmonary disease patients(n=120),and the study group was divided into study group A(n=60)and study Group B(n=60),study group A was treated with antibiotics directly,and study group B was adjusted to use antibiotics according to the indicators.PCT,PA,CRP concentrations,adverse reactions and pulmonary function were compared between the two groups.Results The levels of PCT,PA and CRP in the study group were significantly higher than those in the control group(P<0.05).After treatment,the serum PCT,PA and CRP of study group B were significantly lower than that of study group A(P<0.05);the incidence of adverse reactions of study group B was significantly lower than that of study group A(P<0.05).Conclusion During the treatment of COPD,the concentrations of serum PCT,PA and CRP will change with the improvement of pulmonary function,which has certain significance for guiding clinical antibacterial treatment.