食物不耐受与肝源性腹泻的相关性分析

Correlation analysis between food intolerance and hepatogenic diarrhea

目的探讨食物不耐受与肝源性腹泻的关系。方法收集慢性肝病患者895例,比较肝源性腹泻在慢性肝炎(n=408)、肝硬化代偿(n=204)和肝硬化失代偿(n=283)3组间的差异;比较肝硬化患者中,食物不耐受检测阳性率、食物不耐受中度敏感阳性率、食物不耐受高度敏感阳性率、多种食物不耐受发生率这4个指标在肝功能Child-Pugh分级A(n=241)、B(n=133)、C(n=113)3组间的差异;比较上述4个指标在合并和无合并肝源性腹泻的慢性肝病患者中的差异,logistic回归分析食物不耐受与肝源性腹泻的相关性。结果慢性肝炎、肝硬化代偿和肝硬化失代偿3组间肝源性腹泻发生率比较差异有统计学意义(χ^2=45.693,P<0.001);食物不耐受检测阳性率、食物不耐受中度敏感阳性率、食物不耐受高度敏感阳性率、多种食物不耐受发生率在肝功能Child-Pugh分级A、B、C 3组间比较差异有统计学意义(χ^2=31.559,χ^2=14.132,χ^2=36.674,χ^2=38.405,P均<0.001);慢性肝炎、肝硬化代偿和肝硬化失代偿3组中,合并肝源性腹泻者食物不耐受检测阳性率均高于无肝源性腹泻组(χ^2=22.183,χ^2=12.272,χ^2=16.495,P均<0.001);食物不耐受检测阳性均是慢性肝炎、肝硬化代偿和肝硬化失代偿发生肝源性腹泻的独立危险因素[OR=4.656,95%CI(2.346,9.243),P<0.001;OR=3.707,95%CI(1.729,7.946),P<0.001;OR=2.936,95%CI(1.730,4.984),P=0.001]。结论食物不耐受与肝源性腹泻存在一定关联。

Objective To investigate the relationship between food intolerance and hepatogenic diarrhea.Methods A total of 895 cases with chronic liver diseases were collected.The difference of the incidence rate of hepatogenic diarrhea among patients with chronic hepatitis(n=408),liver cirrhosis compensation(n=204)and liver cirrhosis decompensation(n=283)was compared.The differences of the positive rates of food intolerance,food intolerance medium sensitivity,food intolerance high sensitivity and multiple food intolerance were compared among patients with liver cirrhosis Child-Pugh grade A(n=241),B(n=133)and C(n=113).The differences of the positive rates of food intolerance,food intolerance medium sensitivity,food intolerance high sensitivity and multiple food intolerance were compared between patients with and without hepatogenic diarrhea.The correlation between food intolerance and hepatogenic diarrhea was analysed by binary logistic regression.Results There was significant difference in the incidence rate of hepatogenic diarrhea among patients with chronic hepatitis,liver cirrhosis compensation and liver cirrhosis decompensation(χ^2=45.693,P<0.001).There were significant differences in the positive rates of food intolerance,food intolerance medium sensitivity rate,food intolerance high sensitivity and multiple food intolerance positive rate among patients with liver cirrhosis Child-Pugh grade A,B and C(χ^2=31.559,χ^2=14.132,χ^2=36.674,χ^2=38.405,P<0.001).The positive rate of food intolerance in patients of liver diseases with hepatogenic diarrhea was higher than that without hepatogenic diarrhea(χ^2=22.183,χ^2=12.272,χ^2=16.495,P<0.001).The positive detection of food tolerance was an independent risk factor for chronic hepatitis,liver cirrhosis compensation and liver cirrhosis decompensation[OR=4.656,95%CI(2.346,9.243),P<0.001;OR=3.707,95%CI(1.729,7.946),P<0.001;OR=2.936,95%CI(1.730,4.984),P=0.001].Conclusion There is a correlation between food intolerance and hepatogenic diarrhea.