阻塞性睡眠呼吸暂停综合征与2型糖尿病慢性并发症的相关性研究

Correlation between chronic complications of type 2 diabetes mellitus and obstructive sleep apnea syndrome

目的探讨睡眠呼吸暂停低通气综合征(OSAS)与2型糖尿病(T2DM)慢性并发症的关系。方法收集内蒙古科技大学包头医学院第一附属医院2017-01-2018-05住院的年龄在40~65岁的T2DM患者153例资料,记录人口学数据,分析记录生化指标,进行糖尿病慢性并发症和OSAS的筛查,凡是合并酮症、酸中毒、感染等急性并发症以及嗜烟、嗜酒、药物成瘾、精神疾患或者严重器官功能异常者均排除在外。根据是否合并OSAS,分为OSAS组和对照组,成组比较两组间慢性并发症发生率的差异,并采用Spearman相关分析了解OSAS与慢性并发症的相关性。结果OSAS组糖尿病周围神经病变发生率显著高于对照组(45%对26.9%,P=0.017),OSAS组冠心病发生率显著高于对照组,(20%对8.6%, P=0.038),差异均具有统计学意义。Spearman相关分析显示:OSAS与糖尿病周围神经病变(P=0.021)冠心病(P=0.041)呈正相关关系。结论 OSAS可能与T2DM患者发生周围神经病变、冠心病有一定相关性。

Objective To explore the relationship between chronic complications of type 2 diabetes mellitus(T2 DM)and obstructive sleep apnea syndrome(OSAS). Methods The data of 153 hospitalized T2 DM patients aged 40-65 years were collected;the demograhic data was recorded, biochemical indicators were recorded and analyzed, and the patients were screened for chronic complications of diabetes and OSAS. The patients with ketosis, acidosis and infection, and those who were addicted to alcohol,smoking or drug or with mental illness, or severe organ dysfunction were excluded.According to whether OSAS was combined, they were divided into the OSAS group and the control group were divided into groups. The differences in the incidence of chronic complications between the two groups were compared.Spearman correlation analysis was used to determine the relationship between chronic complications and OSAS.Results The incidence of diabetic peripheral neuropathy(DPN)in the OSAS group was higher than in the control group(45% vs. 26.9%, P=0.017). The incidence of coronary heart disease was significantly higher in the OSAS group than in the control group(20% vs. 8.6%, P=0.038). The differences were statistically significant.Spearman correlation analysis showed that OSAS was positively correlated with diabetic peripheral neuropathy(P=0.021)and coronary heart disease(P=0.041). Conclusion OSAS may be associated with peripheral neuropathy and coronary heart disease in patients with T2 DM.