三种方法制备吉非罗齐固体分散体的性质比较

Comparison of Properties of Gemfibrozil Solid Dispersions Prepared by Three Methods

采用3种方法制备吉非罗齐固体分散体,对比吉非罗齐溶出速率及其与辅料相互作用的差异.固体分散体中药物的体外溶出度显著提高,原料药以及溶剂法、冷冻干燥法及研磨法制备的固体分散体2 h内体外溶出度分别为37.37%、98.13%、97.37%、86.73%.通过粉末X射线衍射(PXRD)、傅立叶变换红外光谱(FT-IR)和差示扫描量热(DSC)等技术分析了药物与载体相互作用的特点,溶剂法最优.

Effect on the dissolution rate and interactions between drug and excipients in the solid dispersions of gemfibrozil prepared by three methods.The dissolution rates of the drug in the solid dispersions have been increased significantly.The dissolution rates of the pure drug and the solid dispersions prepared by the solvent,freeze-drying and grinding method are 37.37%,98.13%,97.37%and 86.73%respectively during 2 hours.The characteristics of interactions between drug and carrier were analyzed by powder X-ray diffraction(PXRD),Fourier transform infrared spectroscopy(FT-IR)and differential scanning calorimetry(DSC).Gemfibrozil solid dispersion prepared by solvent method displays the most optimal properties.