瑞芬太尼与舒芬太尼在脑外科手术合并心血管疾病中的麻醉效果比较

Comparison of anesthetic effects between Remifentanil and Sufentanil in brain surgery combined with cardiovascular disease

目的:比较瑞芬太尼与舒芬太尼在脑外科手术合并心血管疾病中的麻醉效果。方法:选取80例行脑外科手术合并心血管疾病的患者作为研究对象,采用随机数字表法将其分为对照组与观察组各40例,对照组给予瑞芬太尼麻醉,观察组给予舒芬太尼麻醉。比较两组麻醉效果,麻醉作用时间、术后清醒时间、气管拔管时间,麻醉诱导前、麻醉诱导时及拔管后的心率(HR)、收缩压(SBP)、血氧饱和度(SpO2)、疼痛程度及麻醉期间不良反应发生情况。结果:观察组麻醉作用时间、术后清醒时间、气管拔管时间明显短于对照组,差异均有统计学意义(P<0.05);麻醉诱导时、拔管后及麻醉消失后观察组HR、SBP及SpO2均明显优于对照组,差异均有统计学意义(P<0.05)。结论:瑞芬太尼与舒芬太尼应用在脑外科手术合并心血管疾病患者中的麻醉效果相当,且安全性好,但舒芬太尼更有利于稳定患者生命体征,麻醉作用时间相对较短,术后清醒时间、气管拔管时间早。

Objective:To observe anesthetic effects of Remifentanil and Sufentanil in brain surgery combined with cardiovascular disease.Methods:Eighty patients with brain surgeries and cardiovascular diseases were enrolled as the subjects.They were divided into control group(n=40)and observation group(n=40)according to the random number table method.For anesthesia,the control group was given Remifentanil,while the observation group was given Sufentanil.Then,the anesthetic effects,the anesthesia time,the postoperative awake time,the tracheal extubation time,and the heart rate(HR),systolic blood pressure,blood oxygen saturation(SpO2)and pain level before the anesthesia induction and during the anesthesia induction and extubation as well as the occurrence of adverse reactions during the anesthesia were compared between the two groups.Results:The anesthesia time of the observation group,the postoperative awake time and tracheal extubation time were significantly shorter than those of the control group;and the differences were statistically significant(P<0.05).The HR,systolic blood pressure and SpO2 during the anesthesia induction,after extubation and after anesthesia disappeared in the observation group were better than those of the control group,and the differences were statistically significant(P<0.05).Conclusions:Remifentanil and Sufentanil are equally effective in brain surgery combined with cardiovascular disease with good safety.However,Sufentanil is more conducive to stabilizing the patients’vital signs with relatively short anesthesia time,early postoperative awake time and early tracheal extubation time.