依帕司他联合甲钴胺治疗糖尿病末梢神经病变的效果观察

Effects of Epalrestat combined with Mecobalamin on diabetic peripheral neuropathy

目的:观察依帕司他联合甲钴胺治疗糖尿病末梢神经病变的效果。方法:选取84例糖尿病末梢神经病变的患者作为研究对象,按照入院顺序将其分为研究组与对照组各42例,对照组给予甲钴胺治疗,研究组在对照组的基础上联合依帕司他治疗。比较两组治疗效果。结果:研究组的治疗总有效率为97.6%(41/42),明显高于对照组的83.3%(35/42),差异有统计学意义(P<0.05);治疗前两组正中和腓总运动神经、感觉神经传导速度比较,差异无统计学意义(P>0.05),治疗后两组正中和腓总运动神经、感觉神经传导速度均明显快于治疗前,且研究组快于对照组,差异有统计学意义(P<0.05);治疗后两组空腹血糖与餐后2 h血糖均明显低于治疗前,差异有统计学意义(P<0.05),治疗前后两组空腹血糖、餐后2 h血糖比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:与单用甲钴胺相比,依帕司他联合甲钴胺治疗糖尿病末梢神经病变的效果更显著,可有效提升临床疗效,改善神经功能,且安全性强。

Objective:To observe effects of Epalrestat combined with Mecobalamin in patients with diabetic peripheral neuropathy.Methods:84 patients with diabetic peripheral neuropathy were enrolled in the study.They were divided into study group and control group according to the order of admission.The control group was treated with Mecobalamin,while the study group was treated with Epalrestat on the basis of that of the control group.Then,the effects of the two groups were compared.Results:The total effective rate of the study group was 97.6%(41/42),which was significantly higher than that of the control group(83.3%,35/42),and the difference was statistically significant(P<0.05).There were no significant differences in the motor and sensory nerve conduction velocities of the median nerve and common peroneal nerve between the two groups before the treatment(P>0.05).However,after the treatment,the motor and sensory nerve conduction velocities of the median nerve and common peroneal nerve were significantly faster than those before the treatment;those of the study group were faster than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the fasting blood glucose and 2 h postprandial blood glucose of the two groups were significantly lower than those before the treatment,and the differences were statistically significant(P<0.05).However,there were no significant differences in the fasting blood glucose and 2 h postprandial blood glucose between the two groups before and after the treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compared with single Mecobalamin,Epalrestat combined with Mecobalamin is more effective in the treatment of diabetic peripheral neuropathy.It can effectively improve the clinical efficacy and improve the neurological function,and is safe.