血栓闭塞性脉管炎病因及发病机制研究进展

Research Advances on Etiology and Pathogenesis of Thromboangiitis Obliterans

血栓闭塞性脉管炎(TAO)在上下肢中小型动脉中比较常见,指的是非动脉粥样硬化、炎症性、节段性血管炎。本病发生病因及发病机制十分复杂,至今未能有统一的定论,在一定程度上导致其治疗方法受到限制。结合国内外有关研究发现,本病发病原因及机制可能和吸烟、感染、免疫炎症介质、遗传、同型半胱氨酸等有关,但随着临床研究不断深入,也有报道指出本病可能与血管内皮细胞损伤、NOD样受体(NLR)P3炎性小体有关。总的来说,TAO的病因及发病机制极为复杂,本文就从其常见的病因与新近研究进行了综述,希望对相关工作有所借鉴。

Thromboangiitis obliterans(TAO) is more common in small and medium arteries of upper and lower extremities, and refers to non-atherosclerotic, inflammatory, segmental vasculitis. The etiology and pathogenesis of this disease is very complicated, and so far there has not been a unified conclusion, which has led to restrictions on its treatment methods to some extent. Combined with research at home and abroad, the pathogenesis and mechanism of this disease may be related to smoking, infection, immune inflammatory mediators, heredity, homocysteine, etc. However, with the deepening of clinical research, it is also reported that this disease may be related to vascular endothelium. Cellular damage, NOD-like receptor(NLR) P3 inflammatory bodies are involved. In general, the etiology and pathogenesis of TAO is extremely complicated. This article reviews its common etiology and recent research, and hopes to learn from related work.