CX3CL1-CX3CR1与年龄相关性黄斑变性发病机制的研究进展

Advances in pathogenesis of age-related macular degeneration with CX3CL1-CX3CR1

年龄相关性黄斑变性(age-related macular degeneration,AMD)是临床老年人常见的致盲性眼病,病因复杂,可造成不可逆的视力损伤。CX3CL1-CX3CR1是一组趋化因子及其特异性受体,通过对机体免疫系统的调控参与全身各项生理功能及病理变化。近年来文献报道CX3CL1及其受体CX3CR1与AMD的发病密切相关,在AMD发病过程中的免疫调节及炎症反应、新生血管生成过程及光损害与氧化应激反应等关键环节起到了调节作用,CX3CR1基因的两个单核苷酸多态性可能导致AMD易感性增加。本文将趋化因子CX3CL1及受体CX3CR1的结构、功能及其在AMD发生、发展中的作用机制研究进行综述,为今后研究及治疗AMD提供新的思路及方向。

Age-related macular degeneration is a common blinding eye disease in the elderly,with complex causes which can lead to irreversible visual impairment.CX3 CL1-CX3 CR1 is a group of chemokines and their specific receptors,which participate in various physiological functions and pathological changes of the body through regulation of the body’s immune system.In recent years,it has been reported that CX3 CL1 and its receptor CX3 CR1 are closely related to the pathogenesis of age-related macular degeneration.They play a regulatory role in key links such as immune regulation,inflammatory response,angiogenesis,light damage and oxidative stress during the pathogenesis of age-related macular degeneration.Two single nucleotide polymorphisms of CX3 CR1 gene may lead to increased susceptibility to age-related macular degeneration.This article will review the structure and function of chemokine CX3 CL1 and its receptor CX3 CR1,as well as the mechanism of their action in the occurrence and development of age-related macular degeneration,providing new ideas and directions for future research and treatment of age-related macular degeneration.