中重度慢性阻塞性肺疾病患者外周血去甲肾上腺素表达水平的研究

Expression level of peripheral blood noradrenaline in patients with moderate to severe chronic obstructive pulmonary disease

目的调查血浆去甲肾上腺素(NE)水平与中重度慢性阻塞性肺疾病(COPD)之间的联系。方法全程随访32例中重度COPD患者1年,患者接受常规药物治疗,分别在研究开始(V0期),第6个月(V1期)和第12个月(V2期)时进行回访、肺功能检查、血浆NE及其他实验室生化指标检测。结果与健康对照组相比,COPD组NE水平明显升高,差异有统计学意义(P<0.05)。在COPD患者中,随时间推移,NE水平有上升趋势,治疗期间出现急性加重的患者NE水平高于未曾加重的患者,且肺功能1秒钟用力呼气量/用力肺活量与NE水平呈负相关(r=-0.211,P=0.039)。结论 COPD患者NE水平在疾病的发生和进展中有一定作用,检测血浆NE水平有利于监测COPD患者的病情变化,进行提前干预,以改善患者的生存预后。

Objective To investigate the association between plasma noradrenaline(NE)level and moderate to severe chronic obstructive pulmonary disease(COPD).Methods Thirty-two patients with COPD conducted the whole course follow up for one year,received the routine medication therapy,and carried out the return visit,pulmonary function examination,plasma NE detection and other laboratory biochemical detections at the beginning of the study(stage V0),in 6 months(stage V1)and 12 months(stage V2).Results Plasma NE level in the COPD group was significantly elevated compared with the healthy control group(P<0.05).In the cases of COPD,the NE level had an upward trend with time lapse.The NE level in the patients with acute exacerbations during treatment was higher than that in the patients without acute exacerbation,moreover FEV1/FVC in the lung function showed the significantly positive correlation with plasma NE level(r=-0.211,P= 0.039).Conclusion NE in the patients with COPD has a certain effect in the occurrence and development of the disease.Detecting plasma NE level is beneficial to monitor the disease condition of the patients with COPD and conduct the intervention in advance for improving their survival prognosis.