中西医结合治疗实热型卒中相关性肺炎36例临床观察

Clinical Observation of 36 Cases of Excessive Heat Syndrome Associated Pneumonia Treated with Chinese and Western Medicine Combined

目的:观察中西医结合治疗实热型卒中相关性肺炎的临床疗效。方法:选取72例实热型卒中相关性肺炎患者作为研究对象,随机分为对照组和观察组各36例,两组ICU住院期间均采用抗感染、化痰、营养治疗、呼吸支持等基础治疗,观察组在上述基础治疗的同时予以大柴胡汤合小陷胸汤,比较两组临床肺部感染评分(CPIS评分)、体温恢复正常时间、白细胞计数、中性粒细胞百分数、C反应蛋白水平等观察指标。结果:治疗后对照组与观察组临床肺部感染评分、体温恢复正常时间比较差异具有统计学意义(P﹤0.05);两组治疗前后比较,白细胞计数、中性粒细胞百分数、C反应蛋白水平相关炎性指标均有显著下降(P﹤0.05);治疗后对照组与观察组比较,观察组白细胞计数、中性粒细胞百分数改善更显著(P﹤0.05),C反应蛋白水平改善不显著(P﹥0.05)。结论:大柴胡汤合小陷胸汤可以显著改善实热型卒中相关性肺炎患者临床症状,一定程度上降低炎性指标,值得临床推广应用。

Objective To the clinical efficacy of combination of Chinese and Western Medicine in the treatment of excessive heat syndrome stroke associated pneumonia.Methods 72 cases of excessive heat syndrome stroke associated pneumonia in intensive care unit(ICU) were selected as the subjects, and 36 cases were randomly divided into control group and 36 observation group. The two groups of patients ICU were treated with basic treatments such as anti-infection, phlegm, nutritional treatment, and respiratory support during their hospitalization. The observation group was given combination of Dachaihu Decoction and Xiaoxianxiong Decoction at the same time as the above basic treatment. The clinical pulmonary infection score(CPIS score), normal time of body temperature recovery, white blood cell count, percentage of neutrophils,and C-reactive protein levels were compared between the two groups. Results There were significant differences between control group and observation group in the clinical pulmonary infection score(CPIS score), normal time of body temperature recovery(P<0.05). Inflammatory index of White blood cell count, percentage of neutrophils,and C-reactive protein levels decreased significantly in the two groups before and after treatment(P<0.05).compared the control group with the observation group after treatment, the improvement of white blood cell count and neutrophils percentage were more significant(P<0.05) and the improvement of C-reactive protein level were not significant in the observation group(P>0.05).Conclusion Combination of Dachaihu Decoction and Xiaoxianxiong Decoction can significantly improve the clinical symptoms and reduce inflammatory index of patients with excessive heat syndrome stroke associated pneumonia, and is worthy of clinical application and popularization.