2型糖尿病并发抑郁症的危险因素及胰岛素干预和抑郁程度关系的研究

Study on the Risk Factors of Depression Complicated with Type 2 Diabetes Mellitus and the Relationship between Insulin Intervention and the Degree of Depression

目的:探讨2型糖尿病并发抑郁症的独立危险因素及胰岛素治疗对抑郁程度的影响。方法:根据抑郁量表评分将299例2型糖尿病患者分为抑郁组159例和非抑郁组140例,再根据治疗方式将抑郁症组分为非胰岛素干预组81例和胰岛素干预组78例。通过汉密顿抑郁量表评分评估患者的抑郁情况,并结合反映糖尿病病情的相关指标,如性别、年龄、体质量指数、是否应用胰岛素、病程、糖尿病并发症数目、糖化血红蛋白、三酰甘油和总胆固醇等,分析可能导致糖尿病患者并发抑郁症的指标及使用胰岛素干预糖尿病与抑郁程度的关系。结果:299例患者中发生抑郁症159例(53.18%),未并发抑郁症140例(46.82%);糖尿病并发抑郁症与糖化血红蛋白(OR=2.680)、年龄(OR=2.431)、女性(OR=3.055)、糖尿病并发症数目(OR=1.802)显著相关;胰岛素治疗组抑郁程度较非胰岛素治疗组轻。结论:年龄、女性、糖化血红蛋白、糖尿病并发症数目是2型糖尿病并发抑郁症的独立危险因素,存在胰岛素治疗适应证的2型糖尿病患者需尽早使用胰岛素控制病情。

Objective:To investigate the risk factors of depression complicated with Type 2 diabetes mellitus and the relationship between insulin intervention and the degree of depression.Methods:299 patients with type 2 diabetes mellitus were divided into depression group(159 cases)and non-depression group(140 cases),according to the score of depression scale,depression group was divided into non-insulin intervention group(81 cases)and insulin intervention group(78 cases).Depression was assessed by Hamilton Depression Scale score,and analyzed the indicators of depression in patients with diabetes mellitus and the relationship between the use of insulin to intervene in diabetes mellitus and the degree of depression by related indicators reflecting the condition of diabetes,such as gender,age,body mass index,insulin use,course of disease,number of chronic complications of diabetes,glycosylated hemoglobin,triacylglycerol and total cholesterol.Results:Among 299 patients,159(53.18%)had depression,140(46.82%)had no depression;diabetes mellitus complicated with depression was significantly correlated with glycosylated hemoglobin(OR=2.680),age(OR=2.431),female(OR=3.055),number of diabetic complications(OR=1.802);the degree of depression in insulin treatment group was lighter than that in non-insulin treatment group.Conclusion:Age,female,glycosylated hemoglobin and the number of complications of diabetes mellitus are independent risk factors for depression in patients with type 2 diabetes mellitus.Patients with insulin therapy indications need to use insulin as early as possible to control their condition.