依达拉奉注射液在急性脑梗死治疗中的应用及不良反应研究

Application of edaravone injection in the treatment of acute cerebral infarction and adverse reactions

目的探究依达拉奉注射液在急性脑梗死治疗中的应用及不良反应.方法选取2017年10月至2018年10月在本院接受治疗并确诊为急性脑梗死患者76例作为研究对象,按投掷硬币法随机分为对照组和观察组,每组38例.对照组患者口服阿司匹林肠溶片+静脉注射血栓通治疗,观察组在此基础上加以依达拉奉注射液治疗,对比两组患者NIHSS评分、CI体积以及不良反应发生情况.结果观察组NIHSS评分较对照组低(P<0.05),CI体积较对照组小(P<0.05),治疗有效率高于对照组(P<0.05),且不良反应发生率低于对照组(P<0.05).结论在急性脑梗死治疗中应用依达拉奉注射液治疗效果明显,可改善患者神经功能,减少脑梗死体积,降低不良反应发生率,药物治疗安全有效,值得临床推广.

Objective To investigate the application and adverse reactions of edaravone injection in the treatment of acute cerebral infarction. Methods A total of 76 patients with acute cerebral infarction who were treated in our department from October 2017 to October 2018 were enrolled in the study. They were randomly divided into control group and observation group according to the method of throwing coins, with 38 cases in each group. Patients in the control group were treated with aspirin enteric-coated tablets + intravenous thrombus, and the observation group were treated with edaravone injection. The two groups of patients were compared with the NIHSS and CI volume and the occurrence of adverse reactions. Results The NIHSS score of the observation group was lower than that of the control group (P<0.05). The CI volume was smaller than that of the control group (P<0.05). The treatment efficiency was higher than that of the control group (P<0.05), and the incidence of adverse reactions was lower than that of the control group (P<0.05). Conclusion The application of edaravone injection in the treatment of acute cerebral infarction has obvious therapeutic effect, which can improve the neurological function of patients, reduce the volume of cerebral infarction, the incidence of ad- verse reactions, and the drug treatment is safe and effective, which is worthy of clinical promotion.