介孔硅基活性氧可控释放纳米体系及其抗肿瘤应用进展

Advances in the mesoporous silica-based reactive oxygen species controlled-release nanosystem and its anti-tumor application

目前,人类在抗肿瘤治疗方面已取得巨大进步,分子靶向药物、单克隆抗体等一系列抗肿瘤新药层出不穷,已使得广大肿瘤患者不同程度地获益;但现阶段临床抗肿瘤治疗均存在不良反应明显、肿瘤耐药等诸多难题。近年来,以介孔氧化硅为载体设计的纳米药物缓控释体系在一定程度上克服了传统抗肿瘤治疗的种种缺点,尤其是介孔硅基活性氧可控释放纳米体系,具有良好的肿瘤靶向性及生物相容性,且对正常组织细胞影响极小,并可经由多种途径发挥显著的抗肿瘤作用,临床应用前景广阔。该文就该体系及其在抗肿瘤方面的应用进展作一综述。

Until now,great progress has been made in anti-tumor therapy.A series of novel anti-tumor drugs,such as molecular targeted drugs and monoclonal antibodies,have been emerging one after another,which have benefited a great number of tumor patients in different degrees.However,there are still many dilemmas in clinical anti-tumor therapy at present,for instance,obvious side effects,tumor resistance and so on.In recent years,the nano drug delivery system with mesoporous silica as the carrier has overcome many flaws of traditional anti-tumor treatment to a certain extent,especially the mesoporous silica nanosystem for controlling reactive oxygen species generation which has excellent tumor targeting property and biocompatibility,and minimal injury effects on normal tissue cells.So it has been regarded as one of the most promising agents in clinical application by playing significant antitumor roles through multiple approaches.This paper reviews this kind of potent nanosystem and its application to anti-tumor therapy.